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By Sun Apr 25 2021 An epidemiological study has shown that not only is non-Th2 a distinct asthma disease, its likely inducer is early childhood exposure to airborne Benzo[a]pyrene, a byproduct of fossil fuel combustion.   Asthma afflicts more than 300 million people worldwide. The most severe manifestation, known as non-Th2, or non-atopic childhood asthma, represents the majority of the cases, greater than 85%, particularly in low-income countries, according to Hyunok Choi, an associate professor at the Lehigh University College of Health. Yet, whether non-Th2 is a distinct disease (or endotype) or simply a unique set of symptoms (or phenotype) remains unknown. “Non-Th2 asthma is associated with very poor prognosis in children and great, life-long suffering due to the absence of effective therapies,” says Choi. “There is an urgent need to better understand its mechanistic origin to enable early diagnosis and to stop the progression of the disease before it becomes severe.

Czech republicHyunok choiLehigh university college of healthEnvironmental health journalLehigh university collegeBenzopyrene may contributeDivergent pheno endotypesSouthern bohemiaசெக் குடியரசுலேஹி பல்கலைக்கழகம் கல்லூரி ஆஃப் ஆரோக்கியம்சுற்றுச்சூழல் ஆரோக்கியம் இதழ்லேஹி பல்கலைக்கழகம் கல்லூரிதெற்கு போஹேமியா