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An experimental treatment can essentially reverse type 1 diabetes in certain types of laboratory mice, according to a series of studies led by University of Utah Health scientists. An injection of the therapeutic agent converts cells that normally control glucose production into ones that generate insulin.
The researchers say giving the animals a single dose of a human antibody that suppress the actions of glucagon, a hormone involved in glucose regulation, sparked a remarkable transformation in the pancreas, leading to a nearly 7-fold increase in insulin cell mass and the suppression of diabetic symptoms. These animals go from requiring insulin injections to never requiring a diabetes treatment again. They maintain normal blood glucose long after we stop the treatment, says William L. Holland, Ph.D., the study s corresponding author and a U of U Health assistant professor of Nutrition and Integrative Physiology. What this implies for millions of people who have type
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Diabetes and the Eye familiarize the readers with the relationship between diabetes mellitus and the visual system. It presents a discussion about the diabetes epidemic and the many ways the disease can cause vision loss, with several types of vision disorders covered in separate chapters. Information about new frontiers in the treatment of ophthalmic disorders is also presented to reflect the advances being made in the clinic.
Key features:
includes a discussion on the diabetes epidemic
covers a wide range of vision disorders, of different parts of the eye
includes information on current practices in eye care and management for diabetic patients
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Children born as a result of fertility treatment have different growth patterns to naturally-conceived children but, by the time they reach the age of 17, they are of similar height, weight and body mass index (BMI), according to research published today (Wednesday) in
Human Reproduction [1].
The study of 81,461 children from the Norwegian Mother, Father and Child Cohort Study (MoBa) and 544,113 teenagers screened for military service and registered in the Armed Forces Health Registry should provide reassurance for parents of children born as a result of assisted reproduction technology (ART) say the researchers.
Although it is known that ART is associated with lower birthweight, the extent to which differences in growth persist during childhood has not been clear. Further research was also needed to see if patterns of growth could be affected by different fertility treatments or underlying subfertility in parents who conceive naturally.
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BOSTON Numerous studies have demonstrated the role of physical activity in improving heart health for patients with type 2 diabetes. But whether exercising at a certain time of the day promises an added health bonus for this population is still largely unknown. Now, research published in
Diabetes Care by Brigham and Women s Hospital and Joslin Diabetes Center investigators, along with collaborators, reports a correlation between the timing of moderate-to-vigorous physical activity and cardiovascular fitness and health risks for individuals who have type 2 diabetes and obesity or overweight.
The research team found that, in its study of 2,035 people, men who performed physical activity in the morning had the highest risks of developing coronary heart disease (CHD), independent of the amount and intensity of weekly physical activity. Men most active midday had lower cardiorespiratory fitness levels. In women, the investigators did not find an association between specific
Lactate, a compound present in sweat, is an important biomarker to quantify during exercise. However, available wearable sensors can cause skin irritation, which calls for the use of different materials. In a recent study, scientists at Tokyo University of Science have developed a soft and nonirritating microfluidic sensor for the real-time measurement of lactate concentration in sweat. This wearable device will help monitor the state of the body during intense physical exercise or work.