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Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure Like a bad water pump that fails to circulate coolant in a car engine, a failing heart struggles to pump blood through the body, causing symptoms of fatigue, shortness of breath, and swelling in the legs and feet. As heart failure progresses, the heart itself becomes increasingly unable to contract effectively, owing to changes in the molecules that control the heart, particularly a small gaseous molecule called nitric oxide. Nitric oxide is carried by red blood cells and acts as a signal to relax arteries and increase blood flow to heart tissue. It is also produced within heart cells, where it chemically combines with proteins in a process known as S-nitrosylation. More than 20,000 known S-nitrosylation events turn proteins on or off, including proteins that make up the heart s beta-adrenergic receptor (βAR) system - the system that regulates the fight-or-flight response that

Walterj kochJonathans stamlerEmily hendersonSylviak reitman family foundationUniversity hospitals in clevelandNational institutes of health heart lungDepartment of pharmacologyBlood instituteCase western reserve university school of medicineLewis katz schoolTemple universityCase western reserve university schoolUniversity hospitalsNational institutesHealth national heart lungEndowed chair