Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure
Like a bad water pump that fails to circulate coolant in a car engine, a failing heart struggles to pump blood through the body, causing symptoms of fatigue, shortness of breath, and swelling in the legs and feet. As heart failure progresses, the heart itself becomes increasingly unable to contract effectively, owing to changes in the molecules that control the heart, particularly a small gaseous molecule called nitric oxide.
Nitric oxide is carried by red blood cells and acts as a signal to relax arteries and increase blood flow to heart tissue. It is also produced within heart cells, where it chemically combines with proteins in a process known as S-nitrosylation. More than 20,000 known S-nitrosylation events turn proteins on or off, including proteins that make up the heart s beta-adrenergic receptor (βAR) system - the system that regulates the fight-or-flight response that
Grant gives Temple, Case Western scientists chance to study pathway behind heart failure
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A Troubled Public Hospital Closed This Doc Is Leading Its Rebirth
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“The Women of the Copper Country” is Michigan Humanities’ choice for the 2021-22 Great Michigan Read. The story takes place in the 1913 copper strike in the Keweenaw Peninsula. (Photo courtesy of Martin Waymire)
MARQUETTE Residents throughout Michigan are invited to join in reading and discussing “The Women of the Copper Country,” Mary Doria Russell’s account of 25-year-old Annie Clements as she stood up for the miners and their families during the 1913 copper strike.
The book is Michigan Humanities’ choice for the 2021-22 Great Michigan Read and was unveiled during March, which is Women’s History Month.