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Of the nine treatments and preventives for COVID-19 authorized for emergency use by the Food and Drug Administration, three are drugs made from so-called monoclonal antibodies. Such drugs provide patients with ready-made antibodies that neutralize the virus, bypassing the body s slower and sometimes less effective process of making its own antibodies.
But such therapies were developed without detailed information about how antibodies interact with the rest of the immune system during COVID-19. Faced with a new, deadly and fast-spreading disease, drug designers started work without knowing whether antibodies ability to activate a variety of immune cells would aid or hinder efforts to control the disease. Such abilities are collectively known as antibody effector functions.
Glioblastoma study could lead to new treatments, including better immunotherapies
Pictured are MRI scans of eight patients with glioblastoma, an aggressive brain tumor. A new study led by Washington University School of Medicine in St. Louis has mapped out detailed molecular and genetic schematics of these tumors, opening the door to potential improved therapies. (Image: Albert H. Kim)
February 11, 2021 SHARE
Glioblastoma is among the most aggressive and devastating of cancers. While rare compared with other cancers, it’s the most common type of brain cancer. Even with intensive therapy, relatively few patients survive longer than two years after diagnosis, and fewer than 10% of patients survive beyond five years. Despite extensive studies focused on genomic features of glioblastoma, relatively little progress has been made in improving treatment for patients with this deadly disease.
A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor.
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