Biomarker of Alzheimer s found to be regulated by sleep cycles
Immune cells known as microglia (turquoise with red dots) surrounding amyloid plaques
Brian Lananna
Brian Lananna
Scientists at Washington University School of Medicine (WUSM) in St. Louis have spent some years investigating the links between circadian rhythm and Alzheimer’s, and have recently been making some real inroads. Following a 2018 study demonstrating how disrupted sleep can accelerate the buildup of toxic plaques associated with the disease, the team has now identified a protein implicated in the progression of the disease that appears highly regulated by the circadian rhythm, helping them join the dots and providing a potential new therapeutic target.
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A tall white man wearing a denim shirt stands in front of a stove. The camera follows his hand as it reaches into a carton of eggs, and then pans out to reveal a cast-iron skillet. Making eye contact with the camera, he points to the egg: “This is your brain.” He points to the skillet. “This is drugs.” With one muscular hand, he cracks the egg into the hot pan. It oozes and sizzles as he slams the skillet down. “This is your brain on drugs.” The camera pans back up to his stare. “Any questions?”