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Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. NAFLD has been difficult to study mainly because we had no good animal model, said corresponding author Dr. Karl-Dimiter Bissig, who was at Baylor during the development of this project and is now at Duke University.
The disease has both genetic and nutritional components, which have been hard to understand in human studies, and murine models until now had not accurately reflected typical characteristics of human livers with the disease.
Part mouse, part human
U.S. FDA to scrutinize vaccine design behind COVID-19 shots linked to blood clots By Julie Steenhuysen and Kate Kelland
FILE PHOTO: Boxes of the Johnson & Johnson COVID-19 vaccine are seen at the McKesson Corporation, in Shepherdsville
CHICAGO/LONDON (Reuters) – With two COVID-19 vaccines now under scrutiny for possible links to very rare cases of blood clots in the brain, U.S. government scientists are focusing on whether the specific technology behind the shots may be contributing to the risk.
In Europe, health regulators said last week there was a possible link between the AstraZeneca Plc vaccine and 169 cases of a rare brain blood clot known as cerebral venous sinus thrombosis (CVST), accompanied by a low blood platelet count, out of 34 million shots administered in the European Economic Area.
Closer to human – mouse model more accurately reproduces fatty liver disease
Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant.
A chimeric mouse model of NAFLD. On the left, a microscopy image of H&E-stained chimeric liver sections showing separation of liver cells from human or murine origin. Note that the fatty, white filling inside human cells is not present in the murine cells. On the right, the bar graph quantifies macro- and microvesicular steatosis (the abnormal retention of fat within the cells) in human and murine chimeric liver tissue. Image courtesy of the authors/
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