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The Mechanism of Brain s Hunger Switch Uncovered

Feeling famished all the time regardless of how much you eat is a struggle experienced by many people. This problem can be dealt with by making dietary or lifestyle changes, but in some cases, it could be a sign of certain medical conditions. When not treated, this constant hunger can lead to severe obesity. A new study, published in Science on April 15, has the potential to pave the way for drugs that can turn off the hunger switch in the brain. Researchers at the Weizmann Institute of Science, the Queen Mary University of London, and the Hebrew University of Jerusalem have shed a light on how the master switch for hunger in the brain, dubbed the melanocortin receptor 4 (MC4 receptor), works and controls the urge to eat, according to multiple press releases from the universities.

Israel generalMoran shalev benamiQueen mary university of londonWeizmann institute of scienceHebrew university of jerusalemWeizmann instituteQueen mary universityHebrew universityஇஸ்ரேல் ஜநரல்ராணி மேரி பல்கலைக்கழகம் ஆஃப் லண்டன்வெய்ஸ்மேன் நிறுவனம் ஆஃப் அறிவியல்ஹீப்ரு பல்கலைக்கழகம் ஆஃப் ஏருசலேம்வெய்ஸ்மேன் நிறுவனம்ராணி மேரி பல்கலைக்கழகம்ஹீப்ரு பல்கலைக்கழகம்

The Hunger Games: Uncovering the Secret of the Hunger Switch in the Brain - Chemistry | Weizmann Wonder Wander

Being constantly hungry, no matter how much you eat, is a daily struggle for people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications.

Israel generalMoran shalev benamiOksana degtjarikVadivel prabaharFabrizio fierroYoav pelegNicolasj rothVidicha chunilalPeterj mccormickLif chanDanny ben zviAmandeep kaur gillJoaquin bottaWeizmann life sciences core facilities departmentQueen mary university of londonHebrew university of jerusalem

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Israel generalR danny ben zvi university hebrew jerusalemWeizmann institute of scienceInstitute weizmannUniversity kevin mary londonCentral developmentAmi the departmentLight newWeizmann instituteHebrew jerusalemPhd herMoran his ben amiஇஸ்ரேல் ஜநரல்வெய்ஸ்மேன் நிறுவனம் ஆஃப் அறிவியல்மைய வளர்ச்சிவெய்ஸ்மேன் நிறுவனம்

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The Hunger Games: Uncovering the secret of the hunger switch in the brain

E-Mail Being constantly hungry, no matter how much you eat - that s the daily struggle of people with genetic defects in the brain s appetite controls, and it often ends in severe obesity. In a study published in Science on April 15, researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes. These findings shed new light on the way hunger is regulated and may help develop improved anti-obesity medications.

Israel generalMoran shalev benamiOksana degtjarikVadivel prabaharFabrizio fierroYoav pelegNicolasj rothVidicha chunilalPeterj mccormickLif chanDanny ben zviAmandeep kaur gillJoaquin bottaWeizmann institute of scienceTauro career developmentLeadership program