Detectives raided homes across several suburbs, including Morisset, Wyee, Kingfisher Shores and Dora Creek.
They seized methylamphetamine, cocaine, cannabis, replica firearms and knives.
Three men and a woman, aged between 36 and 48, were charged with supplying and possessing illegal drugs.
They’re now facing Toronto Local Court.
They’re among 11 people charged as part of Strike Force Loxton so far.