The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust recently announced its 2021 class of the Pew-Stewart Scholars Program for Cancer Research, among them Indian American professor Ansuman Satpathy.
Satpathy, of Stanford University, will investigate the genetic mechanisms of T-cell exhaustion, a phenomenon that arises with chronic immune stimulation during infections and cancers.
The Satpathy lab will investigate the genetic mechanisms of T-cell exhaustion, a phenomenon that arises with chronic immune stimulation during infections and cancers. Cancer immunotherapies work by enhancing the ability of immune cells called T-cells to recognize and destroy tumor cells.
However, this form of treatment is not effective in all patients or cancer types since the action of T-cells are not always sustained. To learn how T-cells become âexhausted,â his lab will employ a suite of genome-based technologies to map genetic changes in tumor-specific T-cells from over 100
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