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Response to DNA damage: The dual role of extramitochondrial cytochrome C

Response to DNA damage: The dual role of extramitochondrial cytochrome C
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Areces foundationSpanish association against cancerSpanish governmentAndalusian regionalதீவுகள் அடித்தளம்ஸ்பானிஷ் சங்கம் எதிராக புற்றுநோய்ஸ்பானிஷ் அரசுஅண்டலூசின் பிராந்திய

Structure of DNA is found to be actively involved in genome regulation

University of Seville The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling that needs to be resolved later. The paper that has now been published by the team led by Felipe Cortés, head of the DNA Topology and Breaks Group at the Spanish National Cancer Research Centre (CNIO), in collaboration with Silvia Jimeno González, professor at the University of Seville and head of the mRNA Transcription and Processing Group at the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), shows that this supercoiling characteristic of DNA’s structure controls gene expression rather than being a mere collateral damage to be solved, as had been thought to date. The results are reported in t

Spain generalSilvia jimeno gonzFelipe cortAndalusian centre for molecular biologyUniversity of sevilleHealth instituteSpanish national cancer research centreSpanish association against cancerEuropean research councilProcessing groupMinistry of scienceBreaks groupAndalusian centreMolecular biologyRegenerative medicineSpanish association against

The structure of DNA is found to be actively involved in genome regulation

E-Mail The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling that needs to be resolved later. The paper that has now been published by the team led by Felipe Cortés, head of the DNA Topology and Breaks Group at the Spanish National Cancer Research Centre (CNIO), in collaboration with Silvia Jimeno González, professor at the University of Seville and head of the mRNA Transcription and Processing Group at the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), shows that this supercoiling characteristic of DNA s structure controls gene expression rather than being a mere collateral damage to be solved, as had been thought to date. The results are reported in the journal Cell

Spain generalSilvia jimeno gonzFelipe cortAndalusian centre for molecular biologyUniversity of sevilleHealth instituteSpanish national cancer research centreSpanish association against cancerEuropean research councilProcessing groupMinistry of scienceBreaks groupAndalusian centreMolecular biologyRegenerative medicineSpanish association against

DNA structure itself is involved in genome regulation

DNA structure itself is involved in genome regulation
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Spain generalSilvia jimeno gonzFelipe cortY medicina regenerativaRna processing groupSpanish national cancer research centreSpanish association against cancerUniversity of sevilleSpanish ministry of scienceEuropean research councilHealth instituteCentro andaluz de biologMedicina regenerativaSpanish ministrySpanish association againstஸ்பெயின் ஜநரல்

Researchers explore link between intestinal microbiota with colon cancer in patients with Lynch Syndrome

Researchers explore link between intestinal microbiota with colon cancer in patients with Lynch Syndrome The researcher Gabriela Debesa, member of the research group at Simbiosis led by Andrés Moya at the Foundation for the Promotion of Health and Biomedical Research of Valencia Region (Fisabio), studied the relationship of the intestinal microbiota with colon cancer in patients with Lynch Syndrome (a hereditary illness that predisposes the development of cancer) using tissue samples in formalin and conserved in paraffin. The main objective was to figure out if it is possible to obtain information of the microbiome based on samples conserved in this way. This was studied in samples of patients with Lynch syndrome that had developed colon cancer and it was compared if there were differences between the bacterial DNA sequences of the intestinal mucous as well as those of the tumors.

Comunitat valencianaGabriela debesaAntonio llombartEmily hendersonFoundation for the promotion of healthBiomedical research of valencia region fisabioTechnical committee of valenciaPublic healthValencian biobanking networkSpanish association against cancerService of medical oncologyBiomedical researchValencia regionLynch syndromeValencian biobankingMolecular oncology