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A Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the Institute s organ-on-a-chip (Organ Chip) technology to identify the antimalarial drug amodiaquine as a potent inhibitor of infection with SARS-CoV-2, the virus that causes COVID-19.
The Organ Chip-based drug testing ecosystem established by the collaboration greatly streamlines the process of evaluating the safety and efficacy of existing drugs for new medical applications, and provides a proof-of-concept for the use of Organ Chips to rapidly repurpose existing drugs for new medical applications, including future pandemics. The research is reported in
Nature Biomedical Engineering.
While many groups around the world have been testing existing drugs for efficacy against COVID-19 using cultured cells, it is well known that cells grown in a dish do not behave like the cells in a living human body, and many drugs that appear effective in lab studies do not work in patients. T
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While the CRISPR-Cas9 gene editing system has become the poster child for innovation in synthetic biology, it has some major limitations. CRISPR-Cas9 can be programmed to find and cut specific pieces of DNA, but editing the DNA to create desired mutations requires tricking the cell into using a new piece of DNA to repair the break. This bait-and-switch can be complicated to orchestrate, and can even be toxic to cells because Cas9 often cuts unintended, off-target sites as well.
Alternative gene editing techniques called recombineering instead perform this bait-and-switch by introducing an alternate piece of DNA while a cell is replicating its genome, efficiently creating genetic mutations without breaking DNA. These methods are simple enough that they can be used in many cells at once to create complex pools of mutations for researchers to study. Figuring out what the effects of those mutations are, however, requires that each mutant be isolated, sequenced, and characteriz
Researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed bistable inflatable structures inspired by origami, raising new possibilities for the future of emergency shelters, pop-up architecture, and even extra-terrestrial structures. Many of.
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atulpmrApril 25, 2021
Refractive optical elements continue to find maximum applications in semiconductor manufacturing. Attractive opportunities are likely to reside in the laser material processing segment.
“While both are forecast to hold a collective share of just-under 1/3
rd of the total market value in 2020, the applications in metrology and fiber and waveguide coupler also account for significant individual value shares in the market,” says a senior market research analyst at Persistence Market Research.
At an estimated yearly growth of just-over 8.5% in the revenue, the global refractive optical elements market is likely to cross the valuation of US$ 300 million in 2020 – indicates a recently published research intelligence report by the company.