Washington [US], January 19 (ANI): In an effort to address a major challenge when analyzing large single-cell RNA-sequencing datasets, researchers from the University of Texas MD Anderson Cancer Center have developed a new computational technique to accurately differentiate between data from cancer cells and the variety of normal cells found within tumor samples.
Credit: MD Anderson Cancer Center
HOUSTON In an effort to address a major challenge when analyzing large single-cell RNA-sequencing datasets, researchers from The University of Texas MD Anderson Cancer Center have developed a new computational technique to accurately differentiate between data from cancer cells and the variety of normal cells found within tumor samples. The work was published today in
Nature Biotechnology.
The new tool, dubbed CopyKAT (copy number karyotyping of aneuploid tumors), allows researchers to more easily examine the complex data obtained from large single-cell RNA-sequencing experiments, which deliver gene expression data from many thousands of individual cells.
CopyKAT uses that gene expression data to look for aneuploidy, or the presence of abnormal chromosome numbers, which is common in most cancers, said study senior author Nicholas Navin, Ph.D., associate professor of Genetics and Bioinformatics & Computational Biology. The tool also helps to i
Males are more likely to test positive for COVID-19, indicates study
Males are more likely to test positive for COVID-19, more likely to have complications and more likely to die from the virus than females, independent of age, according to a new study published this week in the open-access journal
PLOS ONE by Farhaan Vahidy of Houston Methodist Research Institute, US, and colleagues.
As the COVID-19 pandemic unfolds and evolves across the globe, researchers have identified population sub-groups with higher levels of disease vulnerability, such as those with advanced age or certain pre-existing conditions. Small studies from China and Europe have indicated that males tend to experience higher disease severity compared to females. However a comprehensive analysis of COVID sex in a large and diverse US metropolitan area has been lacking.
Morning Newswatch
Posted on
January 15, 2021 by joeym
Males are more likely to test positive for COVID-19 than females are, finds a new study. Houston Methodist Research Institute researchers used data from a large healthcare provider in the Houston, Texas metro area and found males had a higher likelihood of being diagnosed with COVID-19 than females, and were more likely to require ICU care compared to females (34% versus 28%). Study authors say there is a clear and strong association between male sex and COVID-19 susceptibility, complications, and poor outcomes. They note that understanding the sex differences in the disease is a fundamental step toward improved disease management and intervention strategies for both men and women. (EurekAlert!)
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Males are more likely to test positive for COVID-19, more likely to have complications and more likely to die from the virus than females, independent of age, according to a new study published this week in the open-access journal
PLOS ONE by Farhaan Vahidy of Houston Methodist Research Institute, US, and colleagues.
As the COVID-19 pandemic unfolds and evolves across the globe, researchers have identified population sub-groups with higher levels of disease vulnerability, such as those with advanced age or certain pre-existing conditions. Small studies from China and Europe have indicated that males tend to experience higher disease severity compared to females. However a comprehensive analysis of COVID sex in a large and diverse US metropolitan area has been lacking.