Report: Pfizer, Moderna vaccines could have lasting immunity against COVID-19 Based on the data, the second shot should help guard against the virus if re-exposed, health leaders say. Author: Kayland Hagwood Updated: 7:25 PM EDT June 29, 2021 COLUMBIA, S.C. — A positive sign for those who've taken the Pfizer and Moderna vaccines. A new report shows they could lead to lasting immunity against COVID-19 for years to come. "This is actually very reassuring and very good news," Prisma Health Infectious Disease Specialist Dr. Helmut Albrecht said. Based on the data, the second shot should help guard against the virus if re-exposed, according to Albrecht.