E-Mail IMAGE: Provides all-inclusive access to the critical pillars of human gene therapy: research, methods, and clinical applications. view more Credit: Mary Ann Liebert Inc., publishers New Rochelle, NY, December 10, 2020--The phenomenon of AAV capsid-promoter interaction recently seen in the rat central nervous system has now been shown to occur in the non-human primate brain. This interaction can directly determine cell-specific transgene expression, as described in Human Gene Therapy. Click here to read the full-text article free on the Human Gene Therapy website through January 10, 2021. An adeno-associated virus (AAV) contains a single-stranded DNA genome encapsulated in a capsid comprised of three structural proteins.