Skin provides the protective surface for animals and humans and is therefore prone to physical, chemical, and biological injuries. In all but superficial wounds, the capacity to repair by regeneration is lost and the mechanisms involved in wound closure are unable to restore the skin’s original functions. In this context, skin repair is achieved using surgical techniques including skin grafts, and a range of synthetic or biological scaffolds. Wounds impact millions of patients every year and represent a serious cause of morbidity and mortality worldwide. The increase in need for better skin repair, in part due to issues such as the aging population coupled with chronic conditions has driven the development of products to enhance therapeutic outcomes, yet current treatment outcomes are far from ideal and complete replication of the cellular structure and tissue functional requirements of skin remains a challenge. General aims: Address the major drawbacks of available skin substitutes and delivery system platforms. Herein two approaches are proposed, the first one (Chapters 2-3) involves the development and initial in vitro characterization of a 3D multifunctional bioprinted platform based on platelet lysate, which could be used to deliver cells and growth factors to the wound site while providing a supportive network that mimics the native ECM for skin cells to infiltrate and thrive. This system was designed with the aim of providing an advanced alternative to current skin grafts and skin substitutes available for clinical use. The second system proposed (Chapter 4) is based on an electrofluidic approach for control of bioactive molecule delivery into soft tissue model using threads and surgical sutures which was designed with the aim of being used in sutures for surgical wound closure. Methods: (Chapter 2-3) 3D printed HDF-PLGMA bioink were fabricated using a pneumatic extrusion-based 3D Bioplotter. The epidermal-dermal model was fabricated by seeding HaCaT on top of 3D printed HDF-PLGMA constructs. The innervated dermal model was fabricated by seed hNSC H9 neurospheres to the bottom of 3D printed HDF-PLGMA constructs. (Chapter 4) Commonly employed surgical sutures were used to create an adequate fluid connection between the electrodes and a tissue-like 3D hydrogel support. The platform consisted of two reservoirs into which the ends of the thread/suture were immersed. The anode and cathode were placed separately into each reservoir. The thread/suture was taken from one reservoir to the other through the gel. When the current was applied, biomolecules loaded onto the thread/suture were