Read Time: A holy grail for orthopedic research is a method for not only creating artificial bone tissue that precisely matches the real thing, but does so in such microscopic detail that it includes tiny structures potentially important for stem cell differentiation, which is key to bone regeneration. Researchers at the NYU Tandon School of Engineering and New York Stem Cell Foundation Research Institute (NYSF) have taken a major step by creating the exact replica of a bone using a system that pairs biothermal imaging with a heated "nano-chisel." In a study, "Cost and Time Effective Lithography of Reusable Millimeter Size Bone Tissue Replicas with Sub-15 nm Feature Size on a Biocompatible Polymer," which appears in the journal