Could a Vaccine Be Required Before Taking a Cruise? Dec 13, 2020 Have you thought about getting your vaccine passport in order? Because it could very well be a requirement from the cruise lines that you must be immune to COVD-19 before sailing. Norwegian Cruise Line Holdings CEO Frank Del Rio said the company already has its lawyers looking at the legal side of requiring guests to show they have been vaccinated with the COVID-19 vaccine. Cruise Industry Will Have To Build Confidence First Before we see any significant changes in how the cruise industry can operate, they will need to show that cruising can be done safely.