Heart failure impacts more than 6.5 million people in the U.S. As a progressive disease, it worsens over time, leading to a reduced quality of life, greater risk of complications and death. CRT is an established treatment for select patients with heart failure and has been demonstrated to improve survival and quality of life and reduce heart failure-related hospitalizations. "It is commonly stated within the cardiology community that about a third of patients do not respond to CRT," said Michael R. Gold, M.D., Ph.D., Michael E. Assey Professor of Medicine at the Medical University of South Carolina, Charleston. "However, REVERSE shows that with mild heart failure, patient stability is a long-term benefit of CRT, similar to patient improvement. Our current classifications do not give us the full picture of how patients benefit from CRT. We need to redefine our current understanding of CRT response to include stability as a favorable outcome for this patient population."