How the Splicer Gauntlet works in Destiny 2 in brief To start using the Splicer Gauntlet, you need to progress through The Lost Splicer, which is the introductory seasonal quest. This starts as soon as you log in Destiny 2's Season of the Splicer for the first time. You'll have to search for Mithrax in Europa, followed by a visit to the Vex network. It's a rather straightforward quest that shouldn't take longer than 20 minutes, depending on your skills and current gear (the requirement is 1150 Light). By the end, after defeating a boss, you will stumble upon the Paradrome Cube. This is picked up automatically, so don't worry about missing it. Go ahead and finish the quest, which is done at the upgraded H.E.L.M. space. Interact with the Splicer Servitor, acquire the Paradrome Cube, and the quest will be over. Path of the Splicer I will kickstart immediately after, which will grant you the Splicer Gauntlet.