DNA Explainer: What happens if you take one shot of Covaxin and the other of Covishield? A frequent question arises is that can one take Covaxin as a second shot if you have taken Covishield for the first short and vice versa? (Image Source: Reuters) Updated: May 15, 2021, 03:58 PM IST Amid the second wave of the COVID-19 pandemic, India has started the third phase of its vaccination drive across the country. Since this is a new disease and the vaccine to prevent it has been made in a record time, people have their own hesitations and doubts about it. As of now, the Indian government had given nod to two vaccines - AstraZeneca's Covishield and Bharat Biotech's Covaxin. Only recently Russian Sputnik V vaccine has received clearance in India.