Doctor shares second vaccine dose experience Dealing with the COVID vaccine side effects By Cassie Fambro | January 20, 2021 at 9:40 PM CST - Updated January 21 at 5:40 AM BIRMINGHAM, Ala. (WBRC) - Those who might be getting the second dose of the vaccine could see more of a reaction than they experienced with the first. The second dose of the vaccine gives the person the full protection, and it can affect some people more intensely than others. We spoke to Dr. Joy Henningsen when she got her first shot a few weeks ago, and she has now received the second dose of the Pfizer vaccine.