Droperidol Most Effective and Safe Medication for Agitation by Angela Mohan on April 28, 2021 at 6:08 PM Academic Emergency Medicine (AEM). Agitation is a common presentation with symptoms ranging from a state of restlessness to overtly violent behavior and can result in injury to both patients and their caregivers. Study compared intramuscular droperidol, ziprasidone, and lorazepam in patients with acute agitation in the emergency department, using the proportion of patients adequately sedated at 15 minutes as the primary outcome measure. The authors suggest that larger studies are needed to confirm these findings, particularly to address safety outcomes. Source: Medindia Light Treatment Improves Sleep, Depression, Agitation In People With Alzheimer's Disease