Their vaccines on humans. Trials generally consist of 3 clinical phases. Phase one is mainly focused on whether the human body can tolerate the vaccine and the reaction of the immune system phase 2 looks at how high the dosage has to be and phase 3 tests effectiveness whether the vaccine offers protection in everyday life. Normally approval takes about 8 to 10 years but now the process is supposed to go much faster here at the university of to begin hospital phase one is nearing its end. From the data so far we can see that the vaccine is well tolerated and safe and we also hope that the 1st signals of the immune defense which are becoming apparent are also positive she opposed gifts and another German Company is already testing its vaccine on humans beyond tech based in the german city of mines is partnering with the u. S. Pharmaceutical Company Pfizer theyre already combining phases 2. 00 and 3. 00 testing whether the vaccine actually protects against coronaviruses in everyday life beyond tech has around 30000 volunteer test subjects worldwide it hopes to have an approved vaccine before the end of the year the head of germanys medical regulatory body thinks germany is on the right track you dont seem still fit she clucked german Vaccine Developers are well advanced they are in a global premier league. These are modern platform technologies for vaccines i expect that even 2 vaccines could possibly come from germany if there are more so much the better. A vaccine for everyone by early next year thats an ambitious goal that will require a lot more pinpricks. Well other countries are even more ambitious in india even the government is pushing hard for quick results the threat of another serious lockdown has people worried but indian researchers are hard at work trying to find an answer in the form of a vaccine once a vaccine is it a thing should improve its. It should it would also give us consolation on many fronts its reassuring things would be better at least. You wouldnt do that scared walking out in public and maybe you wont have to make the mask or that day in july 2 indian vaccine candidates initiated phase one human trials. This will be administering to what india spread over a dozen states the Indian Government says it feels it has a moral imperative to develop the vaccine and many major indian pharmaceutical brands are eager to oblige. 60 percent of the vaccine supply in the world whether it be Africa Europe or. Anywhere of Indian Origin india is. Perceived and is an important player in the vaccines for supply for the word this pressure however took a political turn india Top Medical Research Body in a letter to trial sites said that the trials should be expedited to have the vaccine ready to launch by mid august this raised serious concerns on whether these extraordinarily expedited trials will be safe and ethical the move was seen by critics as the indian Prime Minister to make a dramatic announcement in his Independence Day speech on aug 15th are rallying on a cry that india can be selfreliant. But after pressure from medical community the government body clarified that no compromises would be made on safety and that the deadline was simply to expedite the trials and. In reality the researchers say that it could take close to a year for the 1st 2 features of the indian vaccine trials to be completed and so far theres been no work. Fewer so. Many vaccine. Which promises. But with close to a 5th of the worlds population of india is seen as crucial to test the efficacy of any covert baxi the rapidly rising burden of the disease and the intent to be selfreliant raises the stakes even further. For more im joined by doctors he told my manager off Research Development and innovation on the v f a thats the German Association of Research Based pharmaceutical companies batali with us so weve just seen india is rushing to get a vaccine but russia has actually Just Announced that its approved the worlds 1st kovi 1000 vaccine itll start in the countries teachers and medical staff but you make of that is that the big breakthrough weve been waiting for. I dont think so theres a big break saw because its made out of a hollow high settings their requirements for such a stray sheep in the e. U. Before it started you would not get this part of development of the russian basing. Marketing or story as asian here for the study thats missing whats whats missing as cyrus vino says to now or no data on a face speedy trial lenses is a requirement an absolute requirement you are a pool but you dont see. What is so important about the face the trial. We try as. Necessary to assess always see if it has the end to safety off the meds this is a big trial it is maybe thousands of participants of different age for example is different almost all the ditties should be people in who are already ahead of it infection and of ourselves not of and you need many thousands of people to shoulder that you are banks and its really safe and effective. And thats why it normally takes 8 to 10 years to develop a new vaccine as weve heard and the other reports but now the scope of 92. 00 we suddenly see that research has across the world in china and india and Even Companies here in europe that they say that they might have a vaccine by the end of this year thats very fast times that possible. Yes it is very fast as there are several reasons says development will be solved 1st is we have experience is a preset up of of tool set is this is us off on its head time so had been some xs in development and sciences makes instead gods will pull faces trial was so sad. Might actually experience for getting airbags in for us all tool just so recent is. Move technologies which i didnt see an Old FashionedDevelopment Techniques and the last thing is always in companies and this in their i call the torah bodies highest priority heth such developments and theres a rare collaborations. Between cerebrally and in a sleepy bird who gets a development to die and aspires to us all so dr tom just very briefly opp based on the fact that we might get a vaccine sooner than normally when are you ready to get vaccinated i am ready to get back soon and it is gone as our Regulatory Agency in europe says this is the mining im so down as even as a green light it was such a big saying i always lie in our agencies if seeing is in the past 2 years its they are doing a gravel truck and they have fish words so its a really the only. If a poor little big since the char really saved and a few questions that that thank you so much. Well time now for your questions and that means its over to our science correspondent williams. How can a cytokine storm be stopped if it is started. Cytokines or are signaling molecules that are released by immune cells and theyre involved in inflammation which is is part of the bodys immune response to the invasion of a pathogen but in coated 19 patients who deteriorate the checks and balances in the immune system can stop working correctly and the immune cells continue to churn out cytokines on mass even when theyre no longer needed then this this huge wave of cytokines begins attacking the bodys healthy tissues as well as infected tissue in this sort of feedback loop cold called a cytokine storm which in many cases can be the primary cause of mortality there are drugs out there for toning down the immune system response that could be effective at preventing an impending cytokine storm in a patients life the corticosteroid a methadone but its a fairly blunt instrument that affects the immune response as a whole several much more specific cytokine inhibitors that have been approved for other conditions like arthritis are currently in testing to see whether they are also effective in coronavirus induced cytokine storms theres also a machine that actively filter cytokines out of the patients blood many times in the course of a day but its still and clinical testing. 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