The nicholas gwen blog is a molecular biologist and best selling popular science. All of his work led into a very big question. What are the positives of something that isnt itself spot for us . If you have something that we humans created like a building or a call and watch, the more you use it, the more one down it gets and then the less functionality. So you can say that the car age is as you use it. But you know, biological organisms are different because when we stress ourselves, when we use our bodies, we do get this damage, but then we can also repair or so. So that means the damage then get turned into becoming stronger in the, in the scientific term is derived from the engine grateful to excite to mrs. Basically how mesa is, is string through adversity getting stronger from stress and becoming more resilient as you actually damage yourself. And home easiest. A company is us throughout our entire lives beginning with the immune system. In early childhood. These hospital incubators are a temporary home through extremely vulnerable babies. The technicians are checking the ventilation, is nothing, and only a minimal amount of particles to the premature baby. Bored at the same time, this is not supposed to be a gym, free environment, shooting infants, some old like tyria is counter productive and cleaning them down to st. Louis team. And these are basically in this phase, the immune system learns how to fight infectious agents from outside when and that is the reason why we dont get sick. So often in our teens and in adulthood, approximately ive had no confidence on how does that look . The a nate immune system with bowman has a built in response protocol. It targets anything that identifies is a danger and only knows one way to fight. In contrast to the adaptive immune system relates required individually this custom find developing sophisticated Defense Mechanisms after facing challenges in the shape of viruses, all bacteria. The whole nice effect stress leading to great to resilience and excessively Clean Environment presents the risk of the immune system. Basically, having Nothing Better to do and set its sides on our own body. Among the potential consequences are allergies. The Children Play outside and get dirty on the other hand. Ringback makes them tough and strengthens their immune defenses. Thats according to the hygiene hypothesis. At least traditionally a popular premise among hell meet his researches. These days to theory is considered too simplistic, but the principle has not been refused. It makes us find blog dug around, and a range of studies on the subject that side of the positive factors. Things 8 experiments with toxic comp tells that taking the moderation hudson the stomach thing effects. When you read studies, for instance, taking wins and then feeding them, weve kilo another pricing, and then youll see that if you keep it at a low dose, these ones will actually live longer than the ones that have not been placed on that or a or thats examples with radioactive radiation, while you take, for instance, mice and then you, you ready aids them. And of course, if you have really, really and height, i radiation, they didnt kanza and die. But if you have a low level of activity live longer than the mice that has just been left alone on, how does this work . High doses of radiation, obviously by saying coach the generation of free radicals through oxidation, they destroyed cells and cause whats called oxidative stress. But in smaller doses, radiation can resist that process. In this case, for a radical service and a look for the body to toughen up from that is home basis and effect of this kind do appear to occur in humans. Studies show the nicholas simmering ship yard workers hod longer than average life spends with some of the findings among radiologists in britain. While the results of a subject of considerable debate, diesel version effects do exist. The exact doses have yet to be determined. So dont try this at home kids assessment blog. What he would like to see is adding a little home uses to our everyday lives. Peer to exercises good view. It might mean a bit of damage to the body due to oxidative stress. But again, in the right dosage it makes it stronger. Plus, according to bind blog, the vegetarian diet can also have a whole mix. This effect. A lot of edible plants, in fact, have a slightly toxic effect for us due to water soluble molecules, they contain cold police steals. They stimulate the gene, the directs Defense Mechanisms at the cellular level, consumed in the right dosage, they help to train our immune system. The this only works however, if the city of the process is in our body or functioning properly. Nicholas the principal could like and if the situation to a Waste Removal service once defective molecules have been detected by the cell. Theyre enclosed in a bubble. And how scenario a garbage truck which then heads off to a kind of recycling yard inside the cell. And molecular waste is then taken apart with many of the constituent elements being reused. This process a prerequisite full of nice effects is called on top of g. Funding the right dosage, however, is far from straightforward. We can the 1st thing we can learn from home. This is just that biology is extremely complex. Its not just as straightforward as if youre trying to fix a car or Something Like that. When youre trying to do something on your body, thats always all of these feedback loops. So if you try to move your body in this direction, it will push back into the other direction. Then you can see, even if it damage yourself, well then you get stronger. But sometimes also when we didnt try somebody go so stronger, we end up in making ourselves riga in the end because of the systems as well. So we just learned that the body and just even a symbol when its really, really complex the, the bottom line, an unhealthy lifestyle isnt good for you. But now and again, a lot of us do like to, lets all head down. And muscle cells goes despite knowing that it can reduce our Life Expectancy and around half of us have an additional contributing factor that they can do little about that global Life Expectancy, cement is several years. Joseph and so women and i, s i a and his team in frankfort are among various researches hes been suspecting a certain culprit for many years. Now. The y chromosome is the one that genetically makes a man a man struggles. I love to start to show us it is relatively clear from large scale studies as a y chromosome is indeed involved in this slightly lower Life Expectancy and the man, the mental chromosomes store Genetic Information and our body cells. We have 23. 00 pairs with one of them determining on gender. While women have 2 x chromosomes, men have an x on the y. I suppose one was in fact the y chromosome is the smallest of all of our chromosomes and contains on the just over 50 genes, the x chromosome of 800. So it really is atanya chrome is im a cool way, was assume that its sold purposes to determine gender, to determine needs that were such as have now come to conclude that the y chromosome plays a major role in male health. The problem is not the chromosome itself, but its slow. Over the years and decades, someones y chromosome stops to deplete connection with errors and cell division. This affects what are called the blood stem cells and the bone marrow that feels new blood cells. Some of them then no longer have a y chromosome. M either so from that the age of 45. 00 or so around 5 percent of man has suffered y chromosome law. So splits x by 60. That figure is between 20 and 25 percent and fish on and among men, age, 70 plus 40 percent, and todd y chromosome loves and photos specific song chromosomes over a lifetime. Lots of the y chromosomes can lead to what scientists call a mosaic jews. The patchwork of cells with different genetic compositions. This can have serious consequences. The less and so i played on studies over the last 2 or 3 years, showing that menus lost this y chromosome. I have a higher likelihood of cardiovascular disease outside has diabetes if its on the classic geriatric disease, Macular Degeneration ticket, which is a gradual loss of vision response on the amount on the whole. So the question then was, how is this possible to become, to assign the team and frank for us, examine blood samples from patients with heart issues and found cells with no y chromosomes fall more frequently. And this is the, this is the healthy group, and this is the group with cardiac, in sufficiency. And you can clearly see how y chromosome last is far more common in the group with cardiac and sufficiency. Another aspect is the patients lacking, the y chromosomes on average dice una from the heart condition. This is borne out and the survival statistics to patients with an artificial Hospital Research group in the us discovered the following. Among life, blood cells with alpha y chromosome can trigger a sickening or scarring in the hot cold fibers this this stiffens up the hot, and compromises is capacity to pump. Its not yet clear whether these results can be applied to humans. The Frankfurt Team are observing a similar process and all cells, but theres still plenty of areas that have yet to be examined, including house accounts of the law. So if the y chromosome dead side give just the only really 2 recommendations at the moment. We know that smoking accelerates the loss of the y chromosome, and so we recommend that men quits indicate answers to the 2nd thing that seems to be imaging. How is that the physical activity on a regular basis has a protective effect . Thats, thats of important key. Some effect the preventative action doesnt always help, which is why the research is aim is to gain a more precise understanding of the harmful effects of y chromosome last, although even then, it will be many years until effective medication has been developed. So for the time being, the gap in Life Expectancy between men and women is set to stay the on the other hand, men often get a better deal in life. They dont go through child who have to go on the pill. This is only ever been available for women that that might change and then a future the at the university of minnesota. A Research Team headed by going to guild of discover a compound that would be suitable for making. And no one hormonal contraceptive pill ferment. Like were, were really targeting a multitude of proteins. I would say probably about 6. And of course the, its very in stages of development. And the one that is the, for as long as the project on average in the wake assets receptor alpha. And so i guess we are at the stage where we have um, i guess the clinic, okay. Im inside the non candidate is called y c t 5 to 9. Im was tested on my own mind. This compound is reducing spar. Im counts. And the thoughts from montezuma and excite coal in the mouse is 35. 00. That is true. And so that is the amount of times that you have for them. And this is the for us to see the effect. 99 percent of the mice rented instead of child. Busy 6 weeks after being taken off the drug they were able to reproduce again plus the side effects minimal. The contraceptive has since been tested on other animals the Company License the compound. They also did a similar amazing studies with rats. And they also found that it was equally effective and also they did not see any side effect. And then they actually also administer the talk to non human prime. Its basically its a monkeys. And again, the most effective and also totally reversible. Following those promising developments, the compound is now being tested in human Clinical Trials. Researches in gemini are also working on alternative contraceptive solutions biochemist claim and steve, born on his team at the university of fi, white up and conducting tests on mice and collaboration with american colleagues. The compound in this case is t d i 11861. It looks by inhibiting the enzyme soluble on the little side place s a c plays an Important Role in activating spence and making the mo tile or able to swim. That means that and then thats this is prevents some swimming rapidly as in the, in effect for moving forward. And it also stops the maturing process. It isnt necessary for the storm, the fumes with an egg. So hes midnight set up estimates the new compounds advantage is that it can take effect within just 30 minutes. And as a 100 percent, success rate preventing fertilize ation for around 2 and a half hours. 24 hours after the injection. The mice is spent, facility was restored before the by white researches move on to clinical studies. They want to make detailed improvements to t. D. I 11861 and produced optimize derivatives of the compound in the and the other compounds are more bio available absorbed, more effective the word i just did it more slowly and work longer here for our objective before starting Clinical Trials is to combine the features and also committing and the results from the animal trials. I confirmed in clinical studies with human subjects, non homeowner contraceptive pills, cause mock, another milestone in gender equality. We have soon, well finally see a fair share of responsibility between men and women. For all potential consequences of romantic and couch. Let us read, why do you have this science question, then send it to us as a video, text or voice mail . If we answer it on the, i will send you a little surprise as that. Thank you. This weeks question comes from Bosnia Herzegovina specialist says, why is it that our teeth dont grow back . Many people lease that teeth as they reach old age rodents like tempest isnt squirrels, have teeth that never stop growing. Whereas over the course of their lives, chunks produce ups of 40000 teeth. Whenever they lose one, a replacement to fluid from behind, the case only on nails in hand keeps on growing. The only replacement for loss tooth is sufficient. Want to understand why we have to look at our tooth formation process or owed on to genesis, which begins in week 6 of pregnancy um milk p stone to form. At this point, the fetus is just 8 millimeters loan. Starting in the 3rd or 4th month. The buds of what will be all permanent teeth, appear in a secondary dental lamina. And once we have one, a milk teeth and wrapped in an average 8 months off to bust before floating else again between the ages of 6. 00 and 9. 00. The june now has sufficient space for the permanent teeth to break through. The imagines about wisdom, teeth and early adulthood is the final stage of ode unto genesis. Looking at all, even lucian humans have no need to adjust that sets of teeth. But with People Living to an increasingly higher age, ill chase me to last longer, too, and on dietary habits caused them to fall out prematurely. Tooth decay, for example, is one of the most Common Health problems in the world today. So if that set of teeth would make a lot of sense for searches around the globe have spent years on the development of regenerative chief at violins, technical university, scientists managed to produce funds that couldnt ferry spend you teach. So the meantime, those will have to make do with oh, school solutions. The people with alzheimers disease become increasingly forgetful and experience problems with orientation and speaking to most patients and their families. The conditions progression is a painful and distressing ordeal. Many patients require support with otherwise routine tasks out time is, is the most common form of dementia and remains and incurable brain disorder. B the medication available to dates to know me and the v 8 the symptoms, but not put in into the new compounds all. However, in development, in may 2023, an American PharmaceuticalsCompany Published the provisional findings for my study on as outside the onto body to none of them up the 47 percent of patients treated with a new compound remain stable on 40 percent. So lets decline in their ability to carry out today the tasks the cabinet soon. There wasnt improvement and cognition. And thats one of the crucial difference of the anti bodies used in the past. And before going to have access to the Drug Research a 100. So it was, they didnt move out of hand in the development of a similar auntie party therapy many years ago. But compounds deployed to data had only a limited effect. The windows sheets folks who do not know the difference is that the minimum oper moves in a central super toxic peptide, upload them dyspeptic across the source of crystallization and plaque formation. So crystal is up to and on. So like through the field of what existing antibody medication likely kind of does break down the blocks and the brain, but does not deliver an improvement to patients mental well being. Today, scientists know that the truck deposits are not the only factor in the onset outside. This is a force to them what we sometimes call the milk made idea. Its been that flex damage the neuron. Somebody move to, to a degree to pop, to one is perfect heart device month today, or we know that the link them up peptides. These are gonna clumps of toxic peptides that are free christmas to the plaque deposits. Play a very big part in disrupting the nervous system from the staff as the students are from the study in the us launched in the 1980s provided early indications to not only plucks were to blame it, examined around 600 nuns age between 76 and a 107 at that time of day one, conspicuous finding it was that the intellectual faculties had evidently not been compromised. Despite the l summer plucks. Even nuns with a large number of products and their brains were still able to perform mentally challenging tasks right. Up until that passing didnt understood in whos on the we were fascinated by the nuns study back then. And if this was prompted a lot of scientists to ask themselves with the blacks where the central element in the triggering of the disease. Ringback in the us losing or whether it was in parts of the plaque. So look at that. Were playing a decisive role. Steve up the v, as in victor, one dispute drugs developed to date things to support patients memory capacity. But the results were of limited effect until the development of an antibody treatment tucked in particular components of the flux might to knock them off. Now mean a breakthrough into teen pont is scientific direct to other german assignments. The research associa