Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 us

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model


Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model
On March 13, 2020, the World Health Organization (WHO) officially declared the outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is the virus responsible for the coronavirus disease 2019 (COVID-19), to be a global pandemic.
SARS-CoV-2 is a single-stranded ribonucleic acid (RNA) betacoronavirus that shares 95% genomic sequence similarity with SARS-CoV-1, which was a coronavirus that spread throughout many countries in 2002. Scientists around the world are working tirelessly to develop effective vaccines to contain the COVID-19 pandemic.
Previous research has indicated that the spike (S) protein is an important target for emerging vaccines, as well as therapeutics. To date, most of the COVID-19 vaccines have been designed on the basis of the entire S antigen or a truncated form that can induce host immune responses and protect the body from viral infection.

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