Jun 10, 2021 Pratishtha Tiwari Losing belly fat in your 40s Shedding kilos from your midriff has never been easy for anyone and even more difficult in your 40s. TIMESOFINDIA.COM Age is just a number In your 40s, you are more susceptible to weight gain, which is pretty hard to lose. Istock What leads to weight gain in the 40s Age-related weight gain is usually genetic but there are certain other factors that can cause it. Hormones, muscle loss, low metabolism and poor diet can also play a role. Istock Losing belly fat in 40s Belly fat is important to lose as it's linked with numerous health issues such as type 2 diabetes, high blood pressure, high cholesterol and heart disease. Here are some exercises to lose belly fat.