Frequency of multiple changes to prespecified primary outcom

In this meta-research study, Martin Holst and colleagues investigate changes to prespecified primary outcomes in the historic registries of clinical trials.

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Germany , German , , Research Of Germany Bundesministerium , Ministry Of Education , Drug Administration Amendments , German Clinical Trials Register , Open Science Framework , Creative Commons Attribution License , Federal Ministry , Drug Administration Amendments Act , Clinical Trials , Randomized Controlled Trials , Clinical Trial Reporting , Measurement , Immunology , Medicine And Health Sciences , Time Measurement , Surgical Oncology ,