Increased urbanization has led to the burgeoning of informal settlements in both global regions of the North and the South but evidence suggest that the latter has been immensely affected. Housing debates in such low-income neighbourhoods have focused on how best to improve housing delivery systems with the expectation of improving people’s livelihoods, however, there is an existing lacuna within this broad scholarship that has not been well established; the situation of disability geography. In the global South, the gap is even wider when we consider how a focus on disability has not been integrated into work on urban informal housing which for a long time has overemphasized gender differences predominantly on shelter and legal frameworks. PwDs in informal settlements are exposed to varying challenges that are related to poor health, disaster risks and socio-spatial and economic problems which in turn influence their housing conditions.