How the Johnson & Johnson vaccine efficacy rate compares to Moderna, Pfizer "There's been conversation around, 'Do I want Johnson & Johnson now? Or should I take Moderna or Pfizer?' Our advice is, take the quickest appointment you can get." Author: WGRZ Staff Updated: 12:43 PM EST March 7, 2021 BUFFALO, N.Y. — The Johnson & Johnson vaccine is becoming more readily available, with thousands of Western New Yorkers already receiving the shot. However, 2 On Your Side is still fielding questions about how this vaccine holds up compared to the others. Medical experts say the key aspect to remember is that all of the COVID-19 vaccines are effective in preventing hospitalizations and deaths.