<p>Researchers from Osaka University have found that, after chronic social isolation, one form of ketamine—(<em>R</em>)-ketamine—is effective for restoring neuronal activation in a brain region known as the anterior insular cortex. This restored activation leads to improvements in social impairments in a mouse model of depression. Together, these findings indicate that (<em>R</em>)-ketamine is a promising treatment for social symptoms of depression and may lead to better quality of life for millions of people worldwide.</p>