email article COVID-19 patients treated in a randomized trial with the anti-parasitic drug ivermectin did no better than a placebo group, Colombian researchers said. Median time to recovery among mild COVID-19 patients in the ivermectin group was 10 days versus 12 days among those receiving placebo, and rates of symptom resolution at day 21 were about equal, reported Eduardo López-Medina, MD, of Centro de Estudios en Infectología Pediátrica, and colleagues, writing in But the trial was far from perfect. The initial primary outcome was time from randomization until worsening of symptoms by two points on an ordinal scale, but few patients reached this endpoint in the expected time, meaning the sample size needed to maintain sufficient power was "unattainable." Therefore, the primary endpoint was changed to time from randomization to symptom resolution by day 21, and the original sample size was retained.