Katherine left the ABC medical drama in 2010 She continued: "If I'd known anything about meditation then, or had been talking to a therapist or someone to help me through some of the fear that I was steeped in, I think I would have been more calm in how I approached what boundaries I needed to create to thrive." The 42-year-old mum-of-three joined the hugely popular drama as Dr. Isobel "Izzie" Stevens at the show's beginning in 2005 and remained as part of the main cast for five years. At the time of her departure, the 27 Dresses star left the show to focus on her family.