Recently reversed four decades of policy by declaring that israeli settlements in the west bank are not in violation of international law. We have just returned from the west bank and saw some of those roughly 250 settlements and outposts. But we also visited a brandnew city built by a palestinian for palestinians, high on a hill. ticking holy moley, look at this. This is it. This is the best the best. Whoa youve known adam sandler for longer than you remember. 30 years ago he was hired as a writer, and then cast member of saturday night live. Operaman bye bye we wanted to know why he left snl, about all those movies, and why he chose this new one, a drama. I dont care. It needs to be changed. Do it. But first thats called a perfect pass the sand man wanted to play some pick up hoops. Right on baby. ticking im lesley stahl. Im Bill Whitaker. Im anderson cooper. Im sharyn alfonsi. Im scott pelley. Those stories and more, tonight, on 60 minutes. ticking before we talk about taxsmart investing, whats new . Well, audreys expecting. Twins grandparents we want to put money aside for them, so. Change in plans. Alright, lets see what we can adjust. Wed be closer to the twins. Change in plans. Okay. Mom, are you painting again . You could sell these. Lemme guess, change in plans . At fidelity, a change in plans is always part of the plan. Itheres my career. s more to me than hiv. Lemme guess, change in plans . My cause. And creating my dream home. Im a work in progress. So much goes into who i am. Hiv medicine is one part of it. Prescription dovato is for adults who are starting hiv1 treatment and who arent resistant to either of the medicines dolutegravir or lamivudine. Dovato has 2 medicines in 1 pill to help you reach and then stay undetectable. So your hiv can be controlled with fewer medicines while taking dovato. You can take dovato anytime of day with food or without. 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The most common side effects are headache, diarrhea, nausea, trouble sleeping, and tiredness. So much goes into who i am and hope to be. Ask your doctor if starting hiv treatment with dovato is right for you. So why treat your mouth any differently . Listerine® completes the job by preventing plaque, early gum disease, and killing up to 99. 9 of germs. Try listerine®. Need Stocking Stuffers . Try listerine® ready tabs™. Ey mr. Jonescking stuffers . Find great gifts for everyone on your list this holiday, everybody. With low prices and Free Shipping on millions of items at amazon. Pelley our lives have been transformed by the information age. But whats coming next is likely to be more profound call it the Genetic Information age. We have mapped the human genome and in just the last few years we have learned to read and write d. N. A. Like software. And youre about to see a few breakthroughsinwaiting that would transform human health. For a preview of this revolution in evolution we met George Church a world leading geneticist whose own d. N. A. Harbors many eccentricities and a few genes for genius. We found George Church in here. Most of these are frozen george. Little bits of george that we have edited all in different tubes. Pelley church threw himself into his work literally. His d. N. A. Is in many of the experiments in his lab at harvard medical school. The fully assembled George Church is 65 and 65. Maing the human genome and editing d. N. A. Today, his lab is working to make humans immune to all viruses, eliminate genetic diseases, and reverse the effects of time. One of the things your lab is working on is reversing aging. George church thats right. Pelley how is that possible . Church reversing aging is one of these things that is easy to dismiss to say either we dont need it or is impossible or both. Pelley oh, we need it. Church okay. We need it. Thats good. We can agree on that. Well, aging reversal is something thats been proven about eight different ways in animals where you can get, you know, faster reaction times or, you know, cognitive or repair of damaged tissues. Pelley proven eight different ways. Why isnt this available . Church it is available to mice. Pelley in lucky mice, churchs lab added multiple genes that improved heart and kidney function and levels of blood sugar. Now hes trying it in spaniels. So is this gene editing to e reversal . Church this is adding genes. So, its not really editing genes. Its, the gene function is going down, and so were boosting it back up by putting in extra copies of the genes. Pelley whats the time horizon on age reversal in humans . Church thats in Clinical Trials right now in dogs. And so that veterinary product might be a couple years away and then that takes another ten years to get through the human Clinical Trials. Pelley human trials of a personal kind made George Church an unlikely candidate to alter human evolution. Growing up in florida, church was dyslexic, with attention deficit, and frequently knocked out by narcolepsy. What was it that made you imagine that you could be a scientist . Church the thing that got me hooked was probably the new york worlds fair in 1964. Welcome to a journey into the future. Church i thought this is the way we should all be living. When i went back to florida, i said, ive been robbed, you know . Where is it all . And so i said, well, if theyre not going to provide it, then im gonna provide it for myself. Pelley with work and repetition, he beat his disabilities and developed a genius for crystallography a daunting technique that renders 3d images of molecules through xrays and math. But in graduate school at duke, at the age of 20, his mania for the basic structures of life didnt leave time for the basic structure of life. You were homeless for a time. Church yeah. Briefly. Pelley six months. Church six months. Pelley and where were you sleeping when you were homeless . Church well, yeah. I wasnt sleeping that much. I was mostly working. Im narcoleptic. So, i fall asleep sitting up anyway. Pelley his devotion to crystallography was his undoing at duke. Church i was extremely excited about the research i was doing. And so, i would put in 100plus hours a week on research and then pretty much didnt do anything else. Pelley not go to class. Church i wouldnt go to class. Yeah. Pelley duke kicked him out with this letter wishing him well in a field other than biology. But it turned out, harvard needed a crystallographer. George church has been here nearly 40 years. He employs around 100 scientists, about halfandhalf men and women. Who do you hire . Church i hire people that are selfselecting, they see our beacon from a distance away. There are a lot of people that are a little, you know, might be considered a little odd. Neuroatypicals some of us are called. Pelley neuroatypical . Church right. Pelley unusual brains . Church right, yeah. Parastoo khoshakhlagh one thing about george that is very significant is that he sees what you cant even see in yourself. Pelley Parastoo Khoshakhlagh and alex ng are among the neuroatypicals. Theyre engineering human organ tissue. Cory smith i think he tries to promote no fear of failure. The only fear is not to try at all. Pelley cory smiths project sped up d. N. A. Editing from altering three genes at a time to 13,000 at a time. Eriona hysolli went to siberia with church to extract d. N. A. From the bones of wooly mammoths. Shes editing the genes into elephant d. N. A. To bring the mammoth back from extinction. Eriona hysolli we are laying the foundations, perhaps, of de extinction, projects to come. Pelley deextinction. Hysolli yes. Pelley im not sure thats a word in the dictionary yet. Hysolli well, if it isnt it should be. Pelley you know there are people watching this interview who think that is playing god. Church well, its playing engineer. I mean, humans have been playing gihe dn of time. Pelley the point is, some people believe that youre mucking about in things that shouldnt be disturbed. Church i completely agree that we need to be very cautious. And the more powerful, or the more rapidly moving the technology, the more cautious we need to be, the bigger the conversation involving lots of different disciplines, religion, ethics, government, art, and so forth. And to see what its unintended consequences might be. Pelley church anticipates consequences with a full time ethicist in the lab, and he spends a good deal of time thinking about genetic equity. Believing that Genetic Technology must be available to all, not just those who can afford it. We saw one of those technologies in the hands of alex ng and Parastoo Khoshakhlagh. They showed us what they call minibrains, tiny dots with millions of cells each. Theyve proven that cells from a patient can be grown into any organ tissue, in a matter of days, so drugs can be tested on at pat unique nome. You sat cells from georges skin . How does that work . Alex ng we have a way to reprogram, essentially, skin cells, back into a stem cell state. And we have technologies where now we can differentiate them into tissue such as brain tissue. Pelley so you went from georges skin cells, turned those into stem cells, and turned those into brain cells. Ng exactly. Exactly. Pelley simple as that. Organs grown from a patients own cells would eliminate the problem of rejection. Their goal is to prove the concept by growing full sized organs from churchs d. N. A. Church its considered more ethical for students to do experiments on their boss than vice versa, and its good to do it on me rather than some stranger because im as up to speed as you can be on the on the risks and the benefits. Im properly consented. And im unlikely to change my mind. Ng we have a joke in the lab, i mean, at some point, soon probably, were going to have more of his cells outside of his body than he has himself. Pelley churchs d. N. A. Is also used in experiments designed to make humans immune to all viruses. Church we have a strategy by which we can make any cell or any organism resistant to all viruses by changing the genetic code. So if you change that code enough you now get something that is resistant to all viruses including viruses you never characterized before. Pelley because the viruses dont recognize it anymore . Church they expect a certain code provided by the host that they replicate in. The virus would have to change so many parts of its d. N. A. Or r. N. A. So that it cant change them all at once. So, its not only dead, but it nt mutate to a new place where it could survive in a new host. Pelley yes, hes talking about the cure for the common cold and the end of waiting for organ transplants. Its long been known that pig organs could function in humans. Pig heart valves are routinely transplanted already. But pig viruses have kept surgeons from transplanting whole organs. Churchs lab altered pig d. N. A. And knocked out 62 pig viruses. What organs might be transplanted from a pig to a human . Church heart, lung, kidney, liver, intestines, various parts of the eye, skin. All these things. Pelley whats the time horizon on transplanting pig organs into human beings . Church you know, 25 years to get into Clinical Trials. And then again it could take ten years to get through the Clinical Trials. Okay, wonderful. Pelley church is a role model for the next generation. You got it working, looks like. Pelley he has cofounded more than 35 startups. Oh, this is incredibly important. Pelley recently, investors put 100milon intth organ work. Another church startup is a dating app that compares d. N. A. And screens out matches that would result in a child with an inherited disease. Church you wouldnt find out who youre not compatible with. Youll just find out who you are compatible with. Pelley youre suggesting that if everyone has their genome sequenced and the correct matches are made, that all of these diseases could be eliminated . Church right. Its 7,000 diseases. Its about 5 of the population. Its about a trillion dollars a year, worldwide. Pelley church sees one of his own genetic differences as an advantage. Narcolepsy lulls him several times a day. But he wakes, still in the conversation, often discoveringt zone. You could do a. Pelley if somebody had sequenced your genome some years ago, you might not have made the grade in some way. Church i mean, thats true. I would hope that society sees the benefit of diversity not just ancestral diversity, but in our abilities. Theres no perfect person. Pelley despite imperfection, church has coauthored 527 scientific papers and holds more than 50 patents. Proof that great minds do not think alike. The best science can tell, it was about four billion years ago that selfreplicating molecules set off the spark of biology. Now, humans hold the tools of evolution, but George Churchwe e original mystery how chemistry became life. Is the most amazing thing about life, thenthpp at all . Church it is amazing in our current state of ignorance. We dont even know if it ever happened ever in the rest of the universe. Its aweinspiring to know that it either happened billions of times, or it never happened. Both of those are mind boggling. Its amazing that you can have such complex structures that make copies of themselves. But its very hard to do that with machines that weve built. So, were engineers. But were rather poor engineers compared to the pseudo engineering that is biological evolution. ticking tic engineering. Isltimately leo designer babies . Go to 60minutesovertime. Com. And now . La di da, what do we have here . Its everywhere. All because of four filthy numbers. 1 8 5 0. How do you explain this . What am i, a professor in explanation . Oh, this ones been its not pure 1850. Arrestingly bold, yet smooth. Drop the carafe 1850 coffee. Quality thats criminal. Were building the most powerful 5g experience for america. Its going to change everything. Thats why the nfl, the new york times, and the developers at snap chose verizon. Were developing 5g ultra wideband for ultrafast speeds and massive capacity. And its how some of the best companies in the world will redefine whats possible. Now, if verizon 5g can help all of them do all of this, imagine what it could do for you. engine idling hi, sounds like were hosting this weekend. Woman its not doorbell ringa so now your mom is off gluten. Oh. uh, i forgot the. i got you. skip to the good part with alkaseltzer plus. I got you. Now with 25 more concentrated power. Nothing works faster for powerful cold relief. Oh, what a relief it is so fast whitaker secretary of state mike pompeo recently announced the u. S. No longer considers israeli settlements in the west bank in violation of international law. The surprise decision reversed four decades of american policy. It drew criticism from allies around the world and alarm from palestinians about the prospects for peace. To get a firsthand look at the politics of peace, we went to the west bank, an area about the size of delaware along the jordan river, where palestinians have long hoped to establish a state. In the city of ramallah, we found a businessman who isnt waiting for the Palestinian Authority and the israelis to hammer out a path forward. Hes trying to build one himself. Bashar masri is the dreamer behind a brandnew city on a hill called rawabi. Everyone told him it was impossible, but today its the biggest construction project in modern palestinian history and the first planned city for palestinians in more than 1,000 years. When you think of the west bank, chances are a las vegas style concert is not what comes to mind. But this is what we found one night in rawabi. 20,000 palestinians jammed the largest amphitheater in the middle east, singing and swaying to the songs of mohammad assaf, one of the most popular performers in the arab world. This truly was music to the ears of bashar masri, the builder of rawabi one of the richest, and on this night, one of the happiest men in the palestinian territories. We saw you in this sea of people with a great big grin on your face. What was goin through your mind . Bashar masri success. Rawabi is a success. A stamp of approval by my people. And its a wonderful feeling. Whitaker a decade ago, masri could only dream of a night like this. With audacity and determination, he made his dream real. Today, rawabi arabic for hills sits gleaming atop a craggy ridge in the middle of the west bank. The streets are lined with neat rows of condos. Since the grand opening in 2015, about 5,000 people have moved in. Theres a school; and a city center that would look at home in the u. S. Sunbelt with upscale Stores Selling high end brands; outdoor cafes; an indoor amusement center, and extreme sports for the adventurous. It looks like youre selling a little bit of the American Dream on the west bank. Masri why not . If the American Dream is a better life, definitely we deserve a better life. Our people deserve a better life. And thats what rawabi should lead to. Whitaker masri has lived the American Dream. He went to college in the u. S. , got into business and became an american citizen. He currently lives the good life in ramallah, the commercial center of the palestinian territories. He turned modest Real Estate Investments into an International Business empire worth hundreds of millions of dollars. He invested about a 150 million in rawabi; he got the gulf state of qatar, a longtime backer of palestinian causes, to buy in for almost a billion dollars. When masri broke ground in 2010, he planted this giant palestinian flag, like he was staking a claim. Whats the significance of this land to you and your city . Masri to me this land is palestine, and