Cleaning and disinfecting public spaces have become increasingly important during the COVID-19 pandemic. Based on Lingnan University in Hong Kong (LU)’s development of a successful free sanitisation service for over 1,000 subdivided flats by a mobile UV-C germicidal system last year, Lingnan University in Hong Kong has achieved another breakthrough by constructing a smart Autonomous UV-C Disinfection Robot to provide thorough and efficient UV disinfection for large indoor establishments. While the whole disinfection process is automatic, it is far more effective and five times faster than manual disinfection with 1:99 diluted bleach.