Mindfulness-based stress reduction may provide benefit to people with migraine Migraine is a neurological disease that can be severely debilitating and is the second leading cause of disability worldwide. Unfortunately, many patients with migraine discontinue medications due to ineffectiveness or side effects. Many patients still use opioids despite recommendations against them for headache treatment. However, in a recent clinical trial from Wake Forest Baptist Health, researchers showed that mindfulness-based stress reduction (MBSR) may provide benefit to people with migraine. Mindfulness-based stress reduction is a mind-body treatment that teaches moment-by-moment awareness through mindfulness meditation and yoga. Mindfulness can also teach new ways to respond to stress, a commonly reported migraine trigger."