New Phase 1 study evaluates prime/boost HIV-1 vaccine formulated with combinations of adjuvants A new Phase 1 vaccine study began today that will evaluate experimental prime/boost HIV-1 vaccine regimens formulated with combinations of different adjuvants, including one from the Army Liposome Formulation (ALF) family of adjuvants developed by scientists with the U.S. Military HIV Research Program (MHRP) at the Walter Reed Army Institute of Research. An adjuvant is a component of a vaccine that can help make it more effective by improving the immune response or causing the immune response to last longer. The goal of the new trial, RV460, is to evaluate whether an adjuvant can improve immune response to the antigens in the candidate vaccines. It will also help characterize the differences between the adjuvants and the role of adjuvants in priming versus boosting.