Feb 4, 2021 11:05am Scientists at Moffitt Cancer Center showed that immune dysregulation can affect the efficacy of Gilead's CAR-T therapy Yescarta in patients with diffuse large B-cell lymphoma. (Moffitt Cancer Center) CAR-T therapy, which involves modifying a patient’s own T cells to better recognize and destroy cancer cells, offers a valuable treatment option for some people with blood cancers. But it doesn’t work for every patient. In a new study published in the journal Blood, scientists at Moffitt Cancer Center showed immune dysregulation might be to blame for lackluster responses to Gilead Sciences’ CAR-T therapy Yescarta among patients with diffuse large B-cell lymphoma (DLBCL).