1. In this cross-sectional study with 669 individuals, a 3-dimensional endophenotype was identified to elucidate the neuroanatomical, clinical and genetic heterogeneity of autism spectrum disorder. 2. There are partially overlapping neuroimaging and genetic signatures between individuals with autism spectrum disorder, schizophrenia and the general population. Evidence Rating Level: 2 (Good) Study Rundown: Autism Spectrum Disorder