Phase transition inside nucleus provides oncogenic function

Phase transition inside nucleus provides oncogenic function to mutant p53 in cancer


Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB)
Cancer has been recently shown to be affected by protein clusters, particularly by the aggregation of mutant variants of the tumor suppressor protein p53, which are present in more than half of malignant tumors. However, how the aggregates are formed is not yet fully understood. The understanding of this process is expected to provide new therapeutic tools able to prevent proteins to clump and cancer progression.
In Brazil, researchers at the Federal University of Rio de Janeiro have identified a key mechanism behind the mutant p53 aggregation process, linked to cancer pathology, opening new paths for the development of novels drugs against the disease.

Related Keywords

Rio De Janeiro , Estado Do Rio , Brazil , , Royal Society Of Chemistry , University Of Rio De Janeiro , Federal University , Chemical Science , Royal Society , Jerson Lima Silva , Lima Silva , ரியோ டி ஜானிரோ , எஸ்டாடோ செய் ரியோ , பிரேசில் , அரச சமூகம் ஆஃப் வேதியியல் , பல்கலைக்கழகம் ஆஃப் ரியோ டி ஜானிரோ , கூட்டாட்சியின் பல்கலைக்கழகம் , இரசாயன அறிவியல் , அரச சமூகம் , ஜெர்சன் லிமா சில்வா , லிமா சில்வா ,

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