Researchers reveal the role of hypothalamic astrocytes in obesity-related hypertension Researchers have succeeded for the first time in demonstrating the role of hypothalamic astrocytes in obesity-related hypertension. In addition, they showed that the hormone leptin is involved in the increase of blood vessels in the hypothalamus of obese mice, contributing of hypertension. Helmholtz Zentrum München led the study and collaborated with Ludwig-Maximilians-Universität München, the Technical University of Munich and the German Diabetes Center. Hypertension is a widespread comorbidity of patients with obesity that greatly increases the risk of mortality and disability. In recent years, researchers have found that a high-calorie diet increases the density of blood vessels (hypervascularization) in the hypothalamus - an important "eating control" area in our brain. Researchers hypothesized that elevated hormone levels of leptin are associated with a higher risk of developing hypertension. However, the exact mechanisms that contribute to the condensed growth of blood vessels in the hypothalamus were unknown.