Researchers review materials used to design biosensors for SARS-CoV-2 detection The SARS-CoV-2 virus is still causing a dramatic loss of human lives worldwide, constituting an unprecedented challenge for society, public health, and economy, to overcome. Currently, SARS-CoV-2 can be diagnosed in two different ways: i) antigen tests (point-of-care, POC) and ii) molecular tests (nucleic acid, RNA, or PCR-polymerase chain reaction). Antigen tests can detect parts of SARS-CoV-2 proteins, known as antigens, via a nasopharyngeal or nasal swab sampling method. The main advantages of POC-test include the high specificity, quick response (less than an hour), and portability, with no need of fixed laboratory facilities.