Researchers Unveil a New Theory Explaining Long-term Pain Relief Stimulation of peripheral nerves warrants consideration early in the care continuum CLEVELAND, March 15, 2021 (GLOBE NEWSWIRE) — A novel theory recently published in the Journal of Pain Research proposes mechanisms by which a 60-day treatment using percutaneous peripheral nerve stimulation (PNS) may recondition the central nervous system (CNS) to restore normal pain processing and provide long-term pain relief for patients. This short-term treatment may replace the need for permanently implanted systems in many patients. Chronic pain may occur due to an imbalance in nerve signal processing within the CNS as a result of reduced healthy inputs coming from within the region of pain. The new theory proposes that increasing healthy neural inputs by stimulating peripheral nerves can recondition the CNS and restore healthy pain processing. Pain relief following a 60-day peripheral nerve stimulation treatment has been reported by some patients to endure for several years or more.