Lancet E Clinical Medicine. COVID-19 is known to damage multiple areas of metabolism that aids in detecting the disease. Among the list, the skin lipidome may also be included, which could have implications for the skin's barrier function. PCR (polymerase chain reaction) test, which involves collecting swab from the back of the throat and the nose, has become the gold standard approach for detecting COVID-19. However the present study demonstrates the efficacy of sebum samples in diagnosing COVID-19. ‘COVID-19 is known to damage multiple areas of the body that aids in detecting the disease. Among the list, the non-invasive skin swab from a skin area rich in sebum may also help detect COVID-19. This simple sebum sampling method promises reliable diagnosis and monitoring of the disease in both healthcare and a non-healthcare setting.