Highlights: Nikola (NASDAQ:NKLA) was the biggest company in terms of market cap to set a new 52-week low. Home Federal Bancorp (NASDAQ:HFBL) was the smallest company by market cap to set a new 52-week low. Over the course of the first half-hour of trading on Tuesday, the following stocks hit new 52-week lows: Nikola (NASDAQ:NKLA) shares set a new 52-week low of $12.62. The stock traded up 0.62%. ACADIA Pharmaceuticals (NASDAQ:ACAD) stock dropped to a yearly low on Tuesday of $20.36. Shares traded down 1.7%. Puyi (NASDAQ:PUYI) shares reached a new 52-week low of $4.46 on Tuesday morning, moving down 1.75%.