Tokyo, May 29: Synucleinopathies are neurodegenerative disorders caused by an aberrant accumulation of a-synuclein, a protein present in the brain and neurons. Incorrect a-synuclein folding results in the production of'seeds,' which attract more a-synuclein proteins to build larger clumps. Although a-synuclein seeds have been discovered in numerous tissues and blood of patients suffering from synucleinopathies, their value as a biomarker is unclear.