Medically Reviewed Aminosalicylates, corticosteroids, and biologics are just some of the drugs your doctor may prescribe to treat UC. Marc Tran/Stocksy A number of effective ulcerative colitis (UC) treatment options are available, but they can't help you if you don't take them. A study published in Intestinal Research in October 2017 concluded that medication adherence is a “significant problem” in the management of inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease. The study noted that not adhering to treatment can result in disease activity relapse, increased healthcare costs, decreased quality of life, and increased rates of disability and death.