The quake and tsunami could reach the thousands the official number killed on the island of Sooner way Z. Is more than 400 Liang Garley felt the earthquake and hasn't been able to contact her family in the coastal city of Polly since the tsunami hit. This really be my house is made by blue even from really sake while looking for my family we are now trying to organize informations because there is thousands of people now has no information is. Resigning as chairman of Tesla after reaching a deal with the U.S. Regulators he was accused of falsely claiming to have secured funding to take the CO make a private he will have to pay a $20000000.00 fine but will remain Tesla's C.E.O. Michelle Krebs is a senior analyst at Auto Trader someone needs to rein him in and you know I think that's of with appointing a chairman of the board and adding a couple of board members and I hope they pick ones that are very valuable or well well speak up and sort of rubber stamp. I think that's actually good for the company or is John since the tank trees amaze breaks it plans again as the Conservative Party conference begins in Birmingham he told The Sunday Times the Prime Minister's check his proposals are the ranged his the former Conservative M.P. Edwina Currie that is not the way to make progress in the Tory Party and this is what happened to him last time isn't it I mean he has stood for prime minister before and he got absolutely nowhere when he actually did it round and counted the number of members of parliament who would actually support him he wasn't good enough reason May says she's acting in the national interest Meanwhile the Information Commissioner's Office says it will look into a security flaw with the Conservative Party Conference app it allowed contact details including the phone numbers of senior politicians to be accessed. A woman from a Russian village believed to be linked to one of the soul's brain nerve agent suspects has told the B.B.C. She recognizes him and he's a military intelligence officer a claim support the findings of an investigative website said the man who gave his name as Bashir of was in fact a highly decorated soldier code and a totally chip eager. The F.B.I. Has begun its investigation into claims of sexual misconduct against President Trump Supremes Court nominee Brett Kavanaugh federal agents examining the accusations by Dr Blass a 4th have contacted a 2nd woman who has come forward Mr Cavanagh denies any wrongdoing President Trump spoke to journalists about the investigation as he prepared to board Air Force One there's never been anybody that would look. Like Judge Kavanaugh I think that is going to work out very well but the F.B.I. I believe is doing a really great job they have been all over. And Kanye West has changed his name to yeah you know it's the news on Twitter he's had the nickname Yeah for a while now and used it for the title of his album released in June that's the 5 Live news now he's here with the support Europe captain Thomas Bjorn held a remarkable performance from Francesco Molinari and Tommy Fleetwood on day 2 at the Ryder Cup as his side extended their advantage over the USA to 4 points in Paris Molinari and Fleetwood made history becoming the 1st pair to win all 4 of their matches at a single Ryder Cup of event the host take a $106.00 lead into today's 12 singles matches and need just 4 and a half points to regain the title in Paris coverage begins here on 5 live at 11 AM Liverpool manager Juergen Klopp says his whole dressing room was done sing after Daniel Sturridge came off the bench to help the rescue a 11 draw against Chelsea in the Premier League club believes the England forward is in the best shape he seen him since taking over at the club that result allowed Manchester City to go top on goal difference that's after they beat Brighton Manchester United's defeat to West Ham means it's now their worst start to a league campaign for nearly 30 years British number one Johan a concert was beaten again this time losing to number 10 seed you get in the China Open 1st round and the title contender Sebastian Vettel says his Ferrari reached its full potential in qualifying but he could only manage 3rd on the grid for today's Russian grown Prix. In Formula One the Sadie's Valtteri Bottas his own poll ahead of his teammate Lewis Hamilton was this is B.B.C. 5 Live from digital only smartphone and tablet and the 5 live weather a mixture of sunny spells strong winds and showers in Scotland will spread into Northern Ireland parts of Wales and Northern England today however most of England Wales will stay nice and dry but a little cloudy PI's in Birmingham of 13 degrees 6. 66. 66666. 6. 666. 6. 6. 66. 666-6636 likes. Dislikes false extra 5 Live breakfast his hear from 6 with Sam Walker and Nicky Campbell in Paris at the Ryder Cup But 1st we joined Dr Chris Smith and the team for 5 live sites this program is prerecord it's a please don't call or text. Hello welcome to 5 Live Science I'm Chris Smith from the NY could scientists in this hour a D.N.A. Repair kits that can fix genetic diseases a U.K. Project launches to clean up 7000 tons of spice junk and a new computer guy that secretly teaches you about electricity plus well in terms of people who have done it we're looking at somewhere in the region of $50000000.00 or even more I mean the highest estimate so about 100000000 to put that in context the total number of people killed in the war is about 17000000 as we head into winter and the flu season we're putting the influenza virus under the microscope the naked scientists for 5 plus. 1st this week scientists in Cambridge have developed a system to fix a class of devastating genetic diseases called mitochondrial enzyme defects Charlie guard the little boy who became a high profile case Great Ormond Street and sadly died last year had one of these diseases they occur in structures called mitochondria which supply ourselves with energy don't function properly this happens because some of the mitochondria which contain their own small pieces of D.N.A. Carry genetic changes or mutations that prevent them from working properly speaking with Katie Gammage from the Medical Research Council zlib or tree of molecular biology has developed a gene editing system that knocks out selectively the defective mitochondria so they are then replaced by healthy working ones severe medical advances are likely to result in the patient not often leaving the hospital serious mobility problems that likely have cognitive difficulties requiring around the clock care most of the time and life can really be very very difficult and in slightly less severe cases being wheelchair bound and struggling to live an independent life we aimed to develop a system that would enable us to target the mutated mitochondrial D.N.A. And take that percentage down from say 90 percent mutated down to 50 percent mutated and hopefully someone who did have clinical disease no longer has any more so you're talking about editing someone's we're talking about selectively removing one entire Sub Pop election Yeah so how on earth did you do that we took some genome engineering tools which had been developed in a different form for different purposes zinc fingers and finger nuclear is to be precise and what these things do is allow to target specific portions of D.N.A. And cut it if you cut the much going to do you know it gets degraded and so if you can selectively cut the versions of the mitochondria genome that have a mutation then you selectively remove the. From the total pool and so hopefully you change the percentage of mutated versus healthy we created these zinc fingers that would be specific to the mutation in this particular mouse that has a relatively mild form of mitochondrial disease and it is it has a mutation which is very similar to human mutation we tested it in mouse cells to see if we could alter this ratio of mutated mutated and then we put it into the mouse so injecting into the bloodstream the genetic instructions for the zinc fingers using a harmless virus that's been repurposed for this kind of thing and this virus really really likes to be taken out by heart cells predominantly we measured the levels of healthy mice got a D.N.A. Versus mutant side of about 70 percent and going down to about $3035.00 cells generally like to maintain a total number of my total D.N.A. Molecules they say it's a 1000 if we've removed say 20 percent of them or 30 percent of them well happen as the remainder will will be replicated and so your Basically every time you remove one molecule you're increasing the chance that it will be replaced by a healthy one how far you away from doing this in humans. The beauty of this approach is that it's generalizable every time we want to target a new mutation all we have to do is reengineer the parts that bind D.N.A. And then it will work that will take us a certain period of time a few months perhaps to design some new ones to have human mutations and then get ourselves into a position to be performing clinical trials in humans that could take a little bit longer we're hoping to have something on the cards within the next year or so are the needs in people he saw her from mitochondria disease different from each other and if so do you have to pay some wise this tool for every single person that you treat there is a pretty broad selection of mitochondrial mutations that occur and humans and cause disease but there are some real standout candidates that appear much more commonly than others for example there's one which accounts for about 30 percent of all my kind of D.N.A. Mutations in humans so there is definitely going to be a required level of reengineering for different people in a personalized medicine kind of approach but a good portion of the population should be served by a handful of these therapies you are just doing this with mitochondrial D.N.A. Are there any risk to the neatly a D.N.A. We can't find any evidence of any activity of what we've developed in the nuclear gene and we took parts of the nuclear gene and looked very very similar to the area in the much control genome that we were targeting and then we assessed the area around it to see if anything had changed and in our experiments we did this we found absolutely no changes in a world where you don't have an effective treatment it's a potential silver bullet obviously there's a lot of caveats that go with that and a lot of optimization and and careful testing and safety assurances it potentially is a very very big change step change for people who suffer from these diseases what a wonderful story Pam damage from the M.R. C's mitochondrial biology unit at Cambridge University and that work was published in the journal Nature Medicine. Now imagine saving up for years to buy your favorite car but in order to get it home you have to drive it through a pile of rusty metal safe to say you're going to damage it well that's actually pretty much what satellites go through with every launch because our planet is surrounded by a sea of orbiting junk left behind after our previous 4 eyes into space now scientists across Europe are grabbing this bull by the horns with an imaginative benign project called remove debris is a clock spoke to sorry Space Center director and leader of the project Al Yeti Currently there are more than 7000 duns of stuff up there in space and that mostly are old satellites or of their final stage of rockets things that have been brutal in orbit maybe you know decades ago and they are still there spinning around some of them have broken into bits it is a problem because the stuff in orbit travels really fast and so even is more fragment hitting a new satellite could destroy this new satellite. Imagine spending all that time researching a brand new satellite only to launch into orbit and then have it destroyed by a piece of space junk. well yemen and his theme is planning to change well what we have done with our partner is to put together a coup sorts sume to them or straight if acknowledges that can be a use the to to move some of these the brit and the project has been sponsored by the european commission on their kind of technologies that we are going to demonstrate outer relatively simple technologies if you want one is annette the so the idea is to capture or your piece of debris with a gnat the and this netter that enveloped the object and then you can drag it down in order to cannot logy that we are going to the most rate in a few months or is a harpoon sold so here is a see me doubt of thing so without a boon your try to capture a your object and then you would pull it down until it burns into the atmosphere ok say you've just on this fast test so took me through it how did it walk ok everything went a very well a sought from the main satellite which she is the size of an old a television set the we have a release out of the fee shell thought of get is maybe the size of a lawful brett the to give people an idea then this has inflated a stature a to be much bigger a so it is more up it as entity of or very out piece of the breit then from the main satellite we have launched a the net the that as capture of the a lot of little debris with these inflatable stature and there's completely enveloped out of debris and saw now is going to the oughta beat we the it and burning to the atmosphere how as all of this control out how would your device know what's a captioned this piece of debris Well in our case we have released our own piece of artificial debris so we knew where it was and that relatively easy to do to recapture it. Matter your the 1st thing that the satellite will have to do is to get closer to the potential target so you would have to have a more sophisticated control of the satellite in order to get closer to your target therefore you can capture it another test that the remove debris team have said job is to use a camera to monitor the speed and shape of debris in order to check how a potential target me after that it's over to trying to hop a plane rather than an attempt to capture this junk but how does it all then get destroyed. The idea is that we are going to law where they are and we saw this junk can burn into the upper atmosphere and normally our satellites out of the zine in a way that they can burn completely in their high atmosphere however you would try to do these maneuvers maybe over the ocean so even in the unlucky case that the little part of your satellite maybe doesn't burn completely the potential fragment then drops into the ocean and either then or even in an area where maybe there is a higher density of Abi dance how do you hype this a walk in the future what we have done was a demonstration of the technology so now that we have shown that the technology is viable we hope to be able to convince all the stakeholders to actually finance such a mission what we magically is just to do a few missions every year where people would agree before hand what is the particle are a piece of debris that we are targeting so you can go up capture these piece of debris and then they orbit it this is what would that they kind of scenario that we have in mind sounds to me like have got a very big job on their hands that was green Yeti from the sorry Space Center and you can watch a video if you wish of project remove debris in action on their website. You're listening to 5 Live Science with me Chris Smith still to come we're marking the 918 flu pandemic and 10 years of the Large Hadron Collider but what's it done for science before though to something highly electrifying. Engineers at Cambridge University have launched a professional computer game to enable players to learn how electricity works it's called Wired and software engineer Dermot Campbell and also engineer internal just rich a progress on its creators Welcome to both of you Dermot Tony to you 1st so briefly describe this game if I play it what do I see Wired Is video game and you control a character who has to get to the top of the building and she goes into various rooms and when you go into a room you'll find that they'll be mechanical DAWs and platforms that can rise up and fuel cells and switches but initially nothing moves because nothing is wired up so what the player has to do is 1st wire up all the components in the room and then they can run through it pulling the switches jumping on the platforms and get out of the room there is a story that runs through it because the player encounters sort of old silly projector screens of various points where there's this slightly eccentric professor who explains about some of the electrical anomaly real life then. Impart some of the learning as well so. Learning through there absolutely but you also then get to find out who that professor is what his relationship is to the player character and the story evolves through that so a lot of educational games tend to be delivered through the classroom so they only ever end up having to be more fun than the lesson that they're replacing and the whole idea with Wired was sort of saying well let's show that engineering is genuinely fun so. Let's deliver it through gaming websites instead of the classes. People can choose to play it so it needs to be at least as far as other games that people choose to play yes so that they're all the way through from the beginning it's been designed with farm as being its primary driving force Well I asked a young person to have a go of it would you like to hear what I mean I recorded having a guy. Hello my name Samir and I'm 12 and I've just been playing this really fun game could Y. It you have to wire up circuits which make doors and platforms me so you can get around a school. And what's short circuited is that you have to wire up machines correctly you have to have a power supply to the machine and also you can have too many machines connected to a power supply and the more machines you have connected to a power supply the machines will go slower. This is a good game because I'm learning something and it's definitely fun to do when you're bored in the holidays. I mean why did you get on the electricity route there Richard why choose that subject I think came from interviewing students for admission over many many years where I was surprised by how many people didn't really understand the concepts behind Bell teaching current and I thought maybe this is something that if we could get people to feel it to experience it to actually interact with it rather than just see it as a load of equations on paper it might help when you're sitting on the interview panel this intake hear them Richard will be assessing students to see if they've played your game because I could be part of the crowd so you're not having a place at Cambridge because you haven't played Why oh no no I don't. Do that I'm just kidding but no seriously I guess you're going to have to wait now to see if this does make a difference when you because if it does actually perform and does seem to educate Vassar version the way your seeking to do yeah I mean I think it's fairly credible the engineering problem solving is in bedded naturally in the gameplay I think we've got that far but that really doesn't help in unless the game catches on unless the game play sufficient you're trying to so you know how the $1000000.00 question is does it catch on well we will have to wait and see Richard Praga and Campbell from the University of Cambridge and thanks also to junior journalist Amelia for praising the game for us. Well skiing in the warm sun is a luxury that many of us absolutely love and it's also good for you up to a point because the ultraviolet rays in sunlight produce the bone boosting hormone vitamin D. In your skin but too much causes some burned skin aging a wrinkles and it's also respond to for skin cancer rates of which more than doubled in r