A new culture dancer team and lets say together parts of our Community Life on the surface of this research is now on the we are living in an era crises world wide around 1000000000 people are suffering from stress related illnesses, and that number is rising civilians highest. The key to resilience is staying healthy, even when theyre faced with lives. Great burden is. Thats what keeps people mentally healthy, in spite of serious crises, while others break down you off with a single and resilience is a natural phenomenon, a whole that in a those people to continue developing. After the experience a catastrophe for traumatic event. A homeless leading researchers are trying to identify the secret to resilience as against both Resilience Research as the name to identify strategies that can help prevent people from developing Mental Illnesses. Which card can we learn to be resilient . The time it was a part of mason been without sticklers to fitness, the greatest loss that of father can experience the light and dark body. Mine son luka was killed here january evening. This was im so small. Lucas mother, helen called me on a saturday morning just after 7. And she just said one thing about lucca, itll data to cause for me. After a Birthday Party got a club look at and his friend freddy, both 16 got into an argument with another group of teenagers. They tried to calm things down, but the situation escalated. He ended with freddie being pushed in front of an oncoming train. Luca was pulled along with him in the way the its a tragedy. The gail by mine chairs would send me and view and vague. Freddys parents, they all agreed for their 2 sons. In 2019, the police appeared at the biggest door early in the morning. The, this wasnt as much as they said, we should sit down. No, no, it was the worst sentence of my life. One who seems really just that one sentence. Your son died last night. Yeah. So what is the word not crushed on the 5th and youre sitting there at the table. You dont want to believe it, but you dont say this cant be happening. Its as if the earth is opening up and sucking your whole soul away. Is that your whole world is collapsing, the less than this interest if in the day, plays out like a bad movie and you dont realize whats happened. You see it, i think you call a few people and then youre sitting at home and moved and we were lucky. The friends came to us very quickly and looked after us. Familiar comes in the show homeless could come a tom good choice. Espend display can truly understand people who cant cope. I felt that to them just how the why did i get to live, but my son doesnt take double checking him on this month or 2 families have been fabulously long and painful. Road ahead. The, the stress and even crises are part of life. Nevertheless, many people stay mentally healthy. The question is, how the largest and center for Resilience Research in europe is in mines, germany. Here, neural scientist and Brain Research or professor is off a kind of research as the mechanisms of mental resilience, mind and transfer. And hes a photographer, what is Mental Health type process . So my interest in this question comes from my very early days as a university student, or a schoolmate and close friend of mine, had a breakdown in the 1st year of his studies. While i was having a wonderful time to me, it was all fascinating and great and new and kept a father. And during that time i watched my friend fall apart and hes outside of it. So it was empty mindful lines. And that made me ask myself on that side, why does it happen to some people not to others as much as you know, and im not even sure what are the risk factors for Mental Illness the, the simplest on to, as thats a really interesting thing is that its not just a really big extreme life of values that can make people mentally ill as a nation wide distribution. Its not just a serious accident, an act of violence, or the death of a loved one. Interesting, but also minor stresses that can affect people. If they occur frequently and over an extended period of time of creating eventually by letting it upside often mentioned congress and kind of want to know. Ringback what do those with resilience do differently to find out kind of, she is conducting a long term study of Healthy People who find themselves in a particularly difficult phase of their lives. Ringback ringback and even Benjamin Lloyd to induce that we take young people who are in this transitional phase, from family and school to adult life. And alex the better leaving a familiar environment. The lesson visit, we see that in this phase of life, stress related illnesses tend to emerge for the 1st time or if theyre pre existing become more severe. He understands which crush stacking every 3 months. The 200 participants in the study, answer questionnaire about their mental state. To what extent have you felt more calm . 4 times in the past 2 weeks. 5 minutes im sitting on a pat train in my way home from work was a bit stressful for and bonds is that some of the sim messic. But in the mornings i would occasionally just make myself a cup of tea and relax for 10 minutes. And then i was able to settle down, ive missed and welcomes for good food and boss. Thats a feeding to drive it as other time one or 2 months. Because we do this every 3 months. We get a very good picture of stress levels over a long period of time. So if i decide so that we can see over that time how strongly they react psychologically to life challenges. And some are affected more, others affected less of a new coffee. I q and when im in the land in the end, this gives us a picture of what mental resilience looks like when encountering stressors. Thats what the last them i just got up as a when at regular intervals, participants come to the institute for a thorough examination. College and this team use m r. I machines to look for indications of how mental stress is processed in the brain and to examine how stress affects the body. To do this, they take blood and hair samples. The non we can measure the concentration of the stress hormone cortisol from a hair sample. Cortez order pushed in one sense to me to repair typically corresponds to one month of hair grow hot. So the analysis of one centimeter, or in this case 3 centimeters, tells us something about the activity of the stress hormone system over the previous 3 months. And so, okay, and im one of the results have been logged to since the study began in 2016. So there is now a large database of information on thats empties, following the fish. Alternately, we want to understand what mechanisms people use to stay mentally healthy in the face of adversity because on supply im on to render these and making this been best. I can then, once we know these mechanisms, veterans is that to utilize or strengthen them, especially in people who do not succeed in doing that. In the village it was moved his titan. Im so thats the study in mind is due to be finished. So college has already identified certain resilience factors, one of which is how positively or negatively the participants themselves assess their stress levels assigned to id say shes with the scientists as a, there seems to be a connection to optimism and the fact that people believe they can somehow cope and be that it will probably work out somehow i need to know and people can, does that seems to be connected to resilience a few months. So someone who cultivates this kind of positive assessment style or develops it over time, is less likely to be affected. Yeah. Should status so can we influence how resilient we are professor insight high interest money on a 1000000 is also conducting research at the Resilience Center in mines. Investigating what makes some people particularly resilient for me is your system for your 1st part. I think this is promising in terms of better understanding psychiatric illnesses for many decades. And weve had our new moderate success in trying to understand how psychiatric illnesses, for example, stress related illnesses such as clinical depression develop interesting well, Psychiatric Research focuses primarily on the clinical picture. The science of resilience is more concerned with Healthy People. I mean, like this 1st exploring the basics, what does resilient behavior even look like . With our colleagues mortgage schmidts . Shes investigating this and mice. No resilience can only be measured in the context of stress. Thats why they put small brown mice in the cage with a much larger and stronger white mounts. The men mission we take male mice, which like almost all of the mile bush grades show territorial behavior this highest. This means that if you place a test mouse with a launch, a mouse and a time cage, the launch a mouse one to accept some will try to scan, will drive it away. This leads to social stress, orange pressed. The brown mouse is removed in order to prevent it from becoming injured. Experiment is repeated for 10 days. They want to know what is the long term effect of this permanent stress on the behavior of the distressed mice. After a days break, they undertake a 2nd experiment of the brown mice or again exposed to the white aggressor mouse. But this time, the white man is in a cage. The researchers now observed the following. How to the previously stressed mice behave . Did he stay away fearfully . Are they brave enough to approach the white aggressor indicate how im going on the steam when the shooting that the mice will resilience . If they always investigated the white mouse a lot because it kind of as if they had never experience stress device and most exploiting on amazon. Because however, we thought this might not be was indian civil. But rather the result of a less than optimal learning process over time. Most of the test mouse has not learned as an option to store that this white mouse strain is potentially dangerous because from these if that was the case, this mouse could not be described as resilient to available to him and hes mostly just confident, but fleischmann, who so is the intrepid mouse, perhaps just to dumb. The researchers investigate this question and a 3rd experiment. Here, 2 large mice are placed behind bars in the cage, the aggressive white one, and the brown one with which the stress little mouse has had no negative experiences. So far, the additional stuff ill just mouse was allowed to freely explode the bumps examined and visit the different social partners and interact with them on the client side. And thats, and we were able to show their a mice that are able to distinguish between the white mouse which comes from the aggressive strain and the brown mouse which is neutral and with whom it has not had any negative experiences. Phone. Grandma is resilient behavior about being able to distinguish between threat and safety. Up to the same view, we currently see of resilient mouse as a mouse that examines the brown mouse in a completely normal and unimpressed manner. Animals and if it keeps its distance from the white mouse, because it has lunch at the white mouse as a potential threats and during the port, we considered this a resilient behavioral c. No time 5 and span of troop. Who that meets resilient behavior in mice doesnt mean simply bravely confronting every impeding danger. But rather waking up the situation and adapting behavior accordingly. The, this is richard ball. This is directly transferable from much to humans from the dock. Theres a lot of doses showing the people who can distinguish between negative stimuli and neutral stimuli, a best to protect it against stress and associated stress related Mental Illness with send gigs class. Also, its easier to express spending patricia conclusions often. And in this respect, were also quite confident that we can use this model to derive. So the new rep on logical funding. So well be able to go show kennasoft. So nice and moving on. Finding her way back to life. Selling big tries to do this every day after the death of her son freddie, the option well and i said because bonnie, for the last time on friday evening when he told me tearfully malim, im off. I told him to have fun. That was our farewell helps the truth kept middle side b. I can still see him in that moment. He wasnt a good mood looking forward to the evening with his friends. Hes been on the head in retrospect, and im glad that the last time we saw each other was a really pleasant moment with which and that we said good bye to each other nicely without knowing that wed never see each other again. On the day of the funeral, the whole town more with the families. Okay. And freddy are very together in the same grave. The other is because of the mind. And then the whole congregation walked a good kilometer here from the church in a funeral procession and color marsh needed supplies that someone its the dish for me. It was like being in a trance of the, the going to have a lot and the burial itself. Of course you notice to that there were a lot of people there seat on im for, but it passes you by and somehow you dont really have any clear memory of the moment for me to be added. And the funeral itself, like this home, happiness, this coffin with both of them. I dont know if i have you. This is the right word by and this burden, which is so heavy. Im like, i already described it is the earth tokens out all that someone accepts the burden for me, that i could now pass it into other hands to come effect is maybe there was a bit of religion in me after all. Because the physical part will be buried for now, but the emotional part of it will take a very long time before this wound is no longer quite so open. He said when the engineer again so often is the Max Planck Institute of psychiatry know scientist elizabeth wants to find out why do some people remain mentally healthy, despite severe stress, while others become ill under the same stress . G mazda cx, one topic we researched was genetic predisposition found on kind of, sorry, could it be that certain people are genetically predisposed to react more or less to stress and therefore more or less the risk of negative defense later on such as depression, post Traumatic Stress disorder on the, the pressure one of the plus come out the should be last, im still elizabeth been to once to know could it be a gene variant that alters our perception of stress. To find out shes tracking down the hormone cord as all an important hormone for our metabolism and immune system thats also released when were under stress. Its regulated by something called the h p. A access. When we experience stress, the brain is activated. This sets off a complex cascade of events in the brain, stress signals are sent to the hypothalamus. This in turn, release as hormones that make their way to the pituitary gland. The pituitary gland then releases its hormones to the gets regal cortex, which instructs our bodies to make extra cortisone to deal with the stress court as all allows all the cells in our body to flood with Additional Energy to 8 in the fight or flight response. Part is what is it was a Health Stress also. So is the main stressful mode and it travels to goodness in the protein or gonna in copper on this, its very important that we will prepared for a stressful event of an in progress or does all binds to receptors in our cells. And thats a good thing, because the receptor as then report back to the brain. Thank you. We have enough cortisol down here. Now. The stress response is been switched off in the brain and we come down again. At least when everythings functioning correctly. Using the interview, many people in the sit interviews, but normally when the situation is o, stress hormone levels should down regulate again because you dont want the young people with this particular gene or type a not so good at this. So for them, the stress hormones stays high for longer. The question been to asks is, why is that . Why are some people not as good at coming down and others . And this is where genetics come into play. One of the genes responsible for our stress regulation is the f k b p 5 gene its activated during stress and ensures that an important enzyme is released. It has the same name as its corresponding gene s k b, p 5. The problems start with too much of it is released then the enzyme which has its way between the stress receptor and the cortisol and thus blocks the stress receptors message to the brain that theres enough court. As all the brain is misinformed, it keeps fire it and we can no longer calm down here. Thank name because we think that the stress causes too much of this f k b p 5 to be released. And the people simply released too much of the stress hormone even off to the slice of stress. And we know that too much of this stressful mon, in the long time, is bad. So many processes, including the brain, which also increases the risk of psychiatric illnesses compliment. The researchers have identified the f k d p 5 gene as one of several important causes of our hormonal stress regulation. The variance in this gene could be partly responsible for why we react with more or less stress. The researchers are now looking for a way to block activity directly at the f k b p 5 gene just to engineer at the institute. This has been investigated in months that have been given this f k b p 5 blocker. With a day, a more resilient to stress and a better able to cope with it. And to the extent that this can be measured in amounts and im always mess some car. The next step is to develop a drug specifically for people in whom distressed gene variant can be detected in the blood and who therefore, presumably have a higher risk of Mental Illness. The, the south of france, psychiatrist, and euro just focus speaking with nick, works and lives in total. Hes considered a pioneer of Resilience Research. The traumatic experiences of his own childhood. Give him a personal perspective. Veering off of the by had a somewhat difficult childhood. Which motivated me to go into research because i wanted to understand how we can find our way back into life after war. Because as i have lost almost my entire family and ill shoot it, such completeness and e as a 4 year old focus was left on his own without a mother or father. Hidden by foster families, he was eventually arrested and narrowly escaped death. The officer said she should be killed doors, so i knew they wanted to kill me and i was all alone a car. And i heard adults say he has no family. He is lost to life. The point when i was a child, i thought this cant be true, but i reject this curse me. That many deep show at the age of 11 sick of a nic already knew that he wanted to become a psychiatrist. After the war, he studied medicine in paris. The memory of