For adults with advanced nonsmall cell lung cancer previously treated with platinumbased chemotherapy, including those with an abnormal alk or e. G. F. R. Gene whove tried an fdaapproved targeted therapy, nivolumab. Opdivo demonstrated longer life and is the most prescribed immunotherapy for these patients. Opdivo significantly increased the chance of living longer versus chemotherapy. No biomarker testing is required with opdivo, though physicians may choose to do so. Opdivo works with your immune system. Opdivo can cause your immune system to attack normal organs and tissues in your body and affect how they work. This may happen any time see your doctor right away if you experience new or worsening cough; chest pain; shortness of breath; diarrhea; severe stomach pain or tenderness; severe nausea or vomiting; extreme fatigue; constipation; excessive thirst or urine; swollen ankles; loss of appetite; rash; itching; headache; confusion; hallucinations; muscle or joint pain; or flushing as this may keep these problems from becoming more serious. These are not all the possible side effects of opdivo. Tell your doctor about all your medical conditions, or lung, breathing, or liver problems. A chance to live longer. Ask your doctor about opdivo. Bristolmyers squibb thanks the patients, nurses, and physicians pelley the bombs in new york and new jersey last week brought the specter of terror home, again. It seems no country is safe, but there is one that is beating fearsome odds. Isis burned through syria and iraq until it hit a firewall, the hashemite kingdom of jordan. The king, abdullah the second bin al hussein, is holding the front and sheltering millions of refugees despite his struggling economy, no oil wealth and precious little water. If the king can keep his balance, jordan may prove that an arab state can remain peaceful, tolerant and modern. The arsonists torching the middle east hope to see him this is not war. These are Jordanian Forces sharpening their edge on a make believe town. Some of their weapons are antique attack helicopters designed originally for vietnam, surplus armored cars that they found online. Jordan cant afford the arsenals of its neighbors; skill is its advantage. And,ho in training from blanks to live ammunition. This is the soldier who ordered the switch. Hes the former head of special forces. He is abdullah the second, the king of jordan. Why live ammo . We shouted. Sense, he yelled. Theres no sense in anything less than lethal because no king of jordan has ever known peace. This is the mosque that you built in honor of your father. Abdullah yeah. Pelley abdullah became king in 1999 on the death of his father, who ruled 47 years. We met the 54yearold at his palace in amman. He knows isis by its arabic acronym, daesh. But whatever you call it, he says the west doesnt realize its in a third world war. Abdullah i think this is the challenge that weve had over the past several years where people look at, you know, is it iraq this year or syria next year . Well, what about libya . What about boko haram or shabaab in africa . We have to look at it from a global perspective. Pelley all of these things need to be attacked at the same time. You cant concentrate on syria one year and then deal with boko haram in another . Abdullah well, the prime example, its as you see the leadership, theyre telling their fighters either dont come to syria or iraq, or moving their command structure to libya. And so, are we going to wait to get our act together to concentrate on libya . And then, you know, do we wait a year or two to start helping the africans deal with boko haram or shabaab . So, weve got to get ahead of the curve because theyre reacting much quicker than we are. Pelley the american strategy in syria and iraq, as you know, is to use u. S. Air power and to train forces on the ground to fight the battle. How do you move forward from here . Abdullah i think the problem with the west is they see a border between syria and iraq, daesh does not. And this has been a frustration, i think, for a few of us in this area with our western coalition partners, for several years. You know, the lawyers get into the act and say, but theres an international border. And we say, for gods sake, isis doesnt work that way. So, if youre looking at it and want to play the game by your rules knowing that the enemy flown more than 1,000 missions against isis in syria in coordination with the u. S. Last year, pilot Muath Kasasbeh was captured. Isis put him in a cage and made a video as they burned him alive. At the time, abdullah had two terrorists in jail. Within hours of that video, you hanged two convicted terrorists here in jordan. Wh d abdullah i think they had to understand that there was no messing around with jordan. And a lot of those that were involved in killing muath in that video and those that were responsible for detaining him and processing him through his captivity have been taken down since. Pelley hes taking down each and every one in the video. Youre going to hunt them down. Abdullah they have been hunted down, quite a lot of them. And those that are still 50 years, we will get them. Pelley those are the rules of his neighborhood. Abdullah reigns over a desert the size of indiana. To his west, the Israeli Palestinian conflict; north, syrias civil war; east, isis in iraq; and south, severe fundamentalist islam in saudi arabia. It is a collision of tribes and religions not confined by borders drawn with a british t tanks. In 1990, king hussein warned george bush to stay out of iraq. In 2003, the son of the king gave the son of the president the same advice. It seems like american president s think they know this region better than you. Abdullah they seem to understand us better than we know each other. And, as a result, you can see the train on the track coming to going that way, its pretty obvious to some of us whats going to happen. And, you know, you can only express your views as much and as emotionally as you can. Pelley youre frustrated by that. Abdullah the ethnic makeup of the region is pretty glaringly obvious for us that live in the region, that advisors and think tanks in the west seem to know us better than we supposedly know ourselves. Everybody was saying six months. And i said, look, you know, if youre saying six months, im saying six years. Were in for the long haul not only in syria and iraq, but for the whole region and for the world, unfortunately. Pelley but isnt there going to have to be a western army of some kind on the ground in order to take the territory . Abdullah enablers. Enablers. Because, at the end of the day, you cant have western troops walking down the street of syrian cities and villages. At the end of the day, you need border in 2014 as the kings soldiers reached out to refugees. He welcomed them even though there were already more than two million Palestinian Refugees whove been in jordan for decades. Why did you allow nearly a million and a half syrians to come into your country . Abdullah well, we really didnt have much choice. I mean, they were flooding across the border, being shot by the syrian regime. And, you know, jordan has always been a place that opens it arms to refugees from many countries, unfortunately. But then, it got to a point where, you know, were now at 20 increase of our population. And the huge burden on our country, were in dire straits. Pelley most of them are in jordanian towns, looking for work, driving up rents. 160,000 syrian kids are in whats the breaking point for your people . Abdullah about a year or two years ago. Unemployment is skyrocketing. Our Health Sector is saturated. Our schools are really going through difficult times. Its extremely, extremely difficult. And jordanians are. Just have had it up to here. I mean, we just cant take it anymore. Pelley theyve had it with unemployment, near 15 . And thats the official rate; its probably higher. There are more than nine millioe half are under the age of 24. Abdullah if anything keeps me up at night, its giving the Younger Generation an opportunity at life. And on the flip side of that, if radicalization is going to imbed itself anywhere in the world or in this region, its going to be disenfranchised youth. And so, if young people in this country are not going to have an opportunity because of the pressure on the economy again, concern at a multimilliondollar campus built to be his new military headquarters. The king who drives his own car, by the way took this campus away from the generals and converted it to a citadel of software, a Business Park for technology. Imagine these logos on the pentagon. Abdullah i believe the world has a stake in the jordanian economy because we are the Success Story of stability in the region. If there wasnt a jordan, we one. So, i think the story of jordan is bigger than the borders of our country. Pelley his borders began in 1916, when abdullahs great great grandfather led the revolt depicted in the movie lawrence of arabia. The king traces his bloodline directly to the prophet muhammad. Islamic extremists, he told us, are outlaws that the faith has dealt with before. The khawarij. What does that mean . Abdullah well, in islam, us traditional muslims, it is not our right to call people heretics. God decides at the end of the day. The jihadists take it upon themselves to call the rest of us heretics, us muslims. Youre in a completely different and worse category. And so, in our traditional history, the outlaws, the khawarij, appeared, really, in the early part of islam. Pelley they were a sect that splintered from islam in the first century. Abdullah yes. And they did horrible atrocities. And as a result, the muslim communities rose up against them and exterminated them. So, they appear throughout history from time to time, and they always meet their end. But as extremists throughout all appear from time to time. Pelley well, in the united states, many people ask, what has gone wrong with islam . Abdullah well, so, if you look at the spectrum and understand that 90 of us are traditionalists and have an affinity for christianity, judaism i mean, were all the three monotheistic religions, us being the younger one and that our faith decrees the understanding of judaism and christianity, then we understand where we all are. Its that misperception with the takfiri jihadists, thats where the fight is. And they represent probably 2 of sunni islam. Thats where the problem is. And if were being pushed into the corner through islamophobia, thats where the danger is, where we, as allies, are not understood. Pelley your concern is that, if islamophobia takes even greater hold, muslims who are not radicalized today will be forced into that corner. Abdullah well, theyre going to feel isolated. Theyre going to feel marginalized. Which is exactly what isis, al qaeda want. I mean, you know, why fly two aircrafts into the twin towers in new york . Its to create hatred from the west towards islam so that you can panic the majority of muslims to feel that theyre victimized and push them over into the extremist camp. Pelley pressure on the king is rising. explosion that explosion, an isis bomb in june, killed seven jordanian soldiers. Abdullah closed the syrian border. In 2014, it looked like this. Now, with the crossing closed, only the long arm of the u. N. Is lifting aid over the line to nearly 100,000 trapped refugees. Jordan says that isis has infiltrated the camp on the syrian side. But even so, the kingdom has just agreed to set up food and water distribution for those who are stranded. After obliterating that mock king whispered to us, god, i miss my old job. The crown of a prince was lighter when he only had to deal with ancient armor. Abdullah speaking in arabic pelley he told the men, our equipment and vehicles are lacking. We will develop them as soon as we can. men shouting long live the king they yelled. Long live the king. You wonder how the kingdom has lived so long with peril on every side, but maybe thats the key. Treacherous borders are like live rounds in training, they raise the stakes. Jordan endures because the price , no two whale flukes are the same. Because your needs are unique, pacific life has been delivering flexible retirement and Life Insurance solutions for more than 145 years. Ask a Financial Advisor how you can Tailor Solutions from pacific life to help little dakotas nose was quivering in fear. Because it knew an ordinary tissue was near. The fiery tissue left her nose sore and red. So dad slayed the problem with puffs plus lotion, instead. Puffs have pillowy softness for dakotas tender nose. With lotion to comfort and soothe when she blows. Dont get burned by ordinary tissues. A nose in need deserves puffs, indeed. Martin president obamas Nuclear Strategy states that while the threat of allout nuclear war is remote, the risk of a Nuclear Attack somewhere in the world has actually increased. When that was written thre rogue nation like north korea. Back then, the u. S. And russia were said to be partners, but that was before russia invaded crimea, using military force to change the borders of europe. And before its president , Vladimir Putin, and his generals began talking about Nuclear Weapons. For generations, Nuclear Weapons have been seen as a last resort to be used only in extreme circumstances. But in this new cold war, the might think. Airlaunched cruise missiles being loaded onto a long range b52 bomber at Barksdale Air force base in louisiana. When you see it close up, its. Its even bigger than you think it is. Gen. Richard clark it is an impressive machine. About 185,000 pounds empty. But its built to carry weapons and gas. Martin Major GeneralRichard Clark commands all of this countrys nuclear bombers. And these are the weapons . Clark yes, sir. It is the primary Nuclear Weapon for the b52. Martin clark told us these are training missiles, so they are not armed with nuclear warheads. A b52 can carry 20 cruise missiles, six under each wing and eight in the bomb bay. Clark so, this is the rotary launcher, and it holds eight airlaunched cruise missiles within the internal bomb bay of the b52. Its a tight fit, but the way it works is, the launcher rotates, martin it looks like the chamber of a revolver. Clark same idea, just much bigger bullets. Martin as the most visible arm of the American Nuclear arsenal, these bombers are meant to send a message to an international audience. Clark we can put this aircraft anywhere we want, anytime we want, and both our allies and our adversaries take note. Martin this is basically a nuclear show and tell . Clark its not just a show and tell because it will deliver. Years, b52s have begun sending that message directly to russia, flying missions not seen since the cold war. It started after vladamir putin changed history by invading an independent country, ukraine, and seizing its republic of crimea. Gen. Phillip breedlove the fact that military force would be used to change an internationallyrecognized border in the central part of europe, that was new. Martin now retired, general supreme allied commander in europe when russia took over crimea. The invasion was carried out by socalled little green men russian soldiers wearing uniforms without insignia but looming in the background were Nuclear Weapons. Was there ever any indication that Vladimir Putin was prepared to use his Nuclear Weapons in any way . Breedlove Vladimir Putin said himself that he would considered raising the alert status of his nuclear force. Himself. Martin putin said he had given an order to his military to be prepared to increase the readiness of his Nuclear Forces if the u. S. And nato tried to block his takeover of crimea. We were not looking for a fight, putin said in this interview, but we were ready for the worstcase scenario. Breedlove they see Nuclear Weapons as a normal extension of a conventional conflict. Martin so, to them, nuclear war is not unthinkable . The use of Nuclear Weapons is not unthinkable. Martin it says so in their military doctrine, signed by putin in 2014. Russia shall reserve the right to use Nuclear Weapons in the event of aggression, when the very existence of the state is in jeopardy. Putin has personally directed nuclear exercises which have increased in both size and frequency, according to breedlove. More threatening . Breedlove certainly they get your attention. Breedlove clearly. Martin and the u. S. Responded with more aggressive exercises of its own. One year after crimea, four b 52s flew up over the north pole and north sea on an exercise called polar growl. The b52s were unarmed, but that little fin on the side of the fuselage identified them as capable of carrying Nuclear Weapons. Hans kristensen what i plotted here are the two routes for these planes. Director of the Nuclear Information project at the federation of american scientists, used google earth to show us the message that sent russia. Kristensen each bomber can carry 20 cruise missiles, a maximum of them. So, were talking about potentially 80 cruise missiles that could have been launched against targets inside russia at this particular time. Martin using the cruise missiles range of 1,500 miles, kristensen plotted his own hypothetical lines showing how far they could potentially reach into russia. And the end points of kristensen yes, each of them go to a facility in russia that could be a potential target for Nuclear Weapons. Martin the russians would look at that and see it as a dry run for an attack on targets inside russia. Clark i guess they can draw the conclusions that they need to draw. Martin 80 cruise missiles in your face. Clark its a lot of firepower. Martin was that the message . Martin the last time American Nuclear bombers flew a mission like that was during the cold war. Clark this was a significant exercise for us. Were training the way we might have to fight. Martin it was an unmistakable warning, but rear admiral steve parode says theres no indication th